Changyou Zhu1, Hongmei Yan2, Yin Zheng3, Heitor O Santos4, Melahat Sedanur Macit5, Ketong Zhao6. 1. Department of Cardiology, Affiliated Jinan Third Hospital of Jining Medical University, Jining Medical University, Jinan, Shandong Province, 250132, China. 2. Department of Dermatology, Jinan Fourth People's Hospital, Jinan, Shandong Province, 250031, China. 3. Department of Cardiology, Hainan Cancer Hospital, No. 6, Changbin West 4th Street, Xiuying District, 570100, Haikou, Hainan, China; Hainan Chengmei International Health Management Center, No. 6, Changbin West 4th Street, Xiuying District, 570100, Haikou, Hainan, China. 4. School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil. 5. Ondokuz Mayis University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Samsun, Turkey. 6. Department of Cardiology, Hainan Cancer Hospital, No. 6, Changbin West 4th Street, Xiuying District, 570100, Haikou, Hainan, China; Hainan Chengmei International Health Management Center, No. 6, Changbin West 4th Street, Xiuying District, 570100, Haikou, Hainan, China. Electronic address: zhaoketong86@sina.com.
Abstract
BACKGROUND & OBJECTIVE: To date, cinnamon supplementation has been investigated due to its antioxidant and anti-inflammatory properties. Several studies have confirmed the effects of cinnamon supplementation on several markers of cardiometabolic health. However, the effects of cinnamon supplementation on inflammation and oxidative stress levels warrant further investigation. Hence, the current meta-analysis was conducted to elucidate the impact of cinnamon supplementation on biomarkers of inflammation and oxidative stress. METHODS: To perform this systematic review and meta-analysis, we employed the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The systematic search of available clinical trials was performed using the following databases: PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, Embase, and Google Scholar, up to January 2020. RESULTS: After removing the duplicates, 1145 studies were eligible for analysis and 12 of them were included in the meta-analysis. The dose of cinnamon powder investigated in the included trials ranged from 1.5 to 4 g/day. Cinnamon supplementation resulted in a significant reduction of C-reactive protein (CRP) (weight mean difference (WMD): -2.22 mg/L, 95 % CI: -3.74, -0.69, P = 0.004) and malondialdehyde (MDA) (WMD: -0.79 mmol/L, 95 % CI: -1.28, -0.29, P = 0.002), and marginally statistical significant decrease in interleukin-6 (IL-6) (WMD: -1.48 pg/mL, 95 % CI: -2.96, -0.01, P = 0.049). Moreover, it was associated with an increase in the total antioxidant capacity (TAC) (WMD: 0.34 mmol/L, 95 % CI: 0.04, 0.64, P = 0.026). However, the levels of intercellular adhesion molecule-1 (ICAM-1) (WMD: 1.53 ng/mL, 95 % CI: -12.03, 15.10, P = 0.82) did not change significantly following cinnamon supplementation. CONCLUSIONS: Cinnamon supplementation may be an adjuvant for reducing inflammation and oxidative stress levels in humans.
BACKGROUND & OBJECTIVE: To date, cinnamon supplementation has been investigated due to its antioxidant and anti-inflammatory properties. Several studies have confirmed the effects of cinnamon supplementation on several markers of cardiometabolic health. However, the effects of cinnamon supplementation on inflammation and oxidative stress levels warrant further investigation. Hence, the current meta-analysis was conducted to elucidate the impact of cinnamon supplementation on biomarkers of inflammation and oxidative stress. METHODS: To perform this systematic review and meta-analysis, we employed the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The systematic search of available clinical trials was performed using the following databases: PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, Embase, and Google Scholar, up to January 2020. RESULTS: After removing the duplicates, 1145 studies were eligible for analysis and 12 of them were included in the meta-analysis. The dose of cinnamon powder investigated in the included trials ranged from 1.5 to 4 g/day. Cinnamon supplementation resulted in a significant reduction of C-reactive protein (CRP) (weight mean difference (WMD): -2.22 mg/L, 95 % CI: -3.74, -0.69, P = 0.004) and malondialdehyde (MDA) (WMD: -0.79 mmol/L, 95 % CI: -1.28, -0.29, P = 0.002), and marginally statistical significant decrease in interleukin-6 (IL-6) (WMD: -1.48 pg/mL, 95 % CI: -2.96, -0.01, P = 0.049). Moreover, it was associated with an increase in the total antioxidant capacity (TAC) (WMD: 0.34 mmol/L, 95 % CI: 0.04, 0.64, P = 0.026). However, the levels of intercellular adhesion molecule-1 (ICAM-1) (WMD: 1.53 ng/mL, 95 % CI: -12.03, 15.10, P = 0.82) did not change significantly following cinnamon supplementation. CONCLUSIONS:Cinnamon supplementation may be an adjuvant for reducing inflammation and oxidative stress levels in humans.
Authors: Ana Paula Rachid; Margarida Moncada; Maria Fernanda de Mesquita; José Brito; Maria Alexandra Bernardo; Maria Leonor Silva Journal: Nutrients Date: 2022-04-10 Impact factor: 6.706
Authors: Maria Leonor Silva; Maria Alexandra Bernardo; Jaipaul Singh; Maria Fernanda de Mesquita Journal: Nutrients Date: 2022-07-05 Impact factor: 6.706