| Literature DB >> 33064789 |
Bernd Jahrsdörfer1,2, Joris Kroschel3, Carolin Ludwig1, Victor Max Corman4, Tatjana Schwarz4, Sixten Körper1,2, Markus Rojewski1,2, Ramin Lotfi1,2, Christof Weinstock1,2, Christian Drosten4, Erhard Seifried5, Thomas Stamminger6, Hans Jürgen Groß3, Hubert Schrezenmeier1,2.
Abstract
Highly sensitive and specific platforms for the detection of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies are becoming increasingly important for evaluating potential SARS-CoV-2 convalescent plasma donors, studying the spread of SARS-CoV-2 infections, and identifying individuals with seroconversion. This study provides a comparative validation of 4 anti-SARS-CoV-2 platforms. A unique feature of the study is the use of a representative cohort of convalescent patients with coronavirus disease 2019 and a mild to moderate disease course. All platforms showed significant correlations with a SARS-CoV-2 plaque reduction neutralization test, with highest sensitivities for the Euroimmun and the Roche platforms, suggesting their preferential use for screening persons at increased risk of SARS-CoV-2 infections.Entities:
Keywords: CLIA; CMIA; ECLIA; ELISA; SARS-CoV-2; neutralization test; nucleocapsid; spike
Year: 2021 PMID: 33064789 PMCID: PMC7665624 DOI: 10.1093/infdis/jiaa656
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226