Jennifer J Schoch1, Nicole Miranda2, Cynthia W Garvan3, Reesa L Monir1, Josef Neu4, Dominick J Lemas5. 1. Department of Dermatology, University of Florida College of Medicine, Gainesville, FL, USA. 2. University of Florida College of Medicine, Gainesville, FL, USA. 3. Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, USA. 4. Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA. 5. Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, FL, USA.
Abstract
BACKGROUND/ OBJECTIVES: Premature infants have lower rates of atopic dermatitis (AD) compared with full-term infants, though little is known about the factors contributing to this association. We explored the infant and environmental factors that may contribute to the association between prematurity and atopic dermatitis, including mode of delivery, birthweight, gestation, and duration of stay in the neonatal intensive care unit (NICU). METHODS: This was a single-center retrospective study. Independent samples t tests or chi-square tests were used to compare groups on continuous and categorical variables, respectively. Logistic regression then examined the association of the predictor variables with AD. RESULTS: Four thousand sixteen mother-infant dyads were included. Infants had a higher risk of developing AD if they were delivered vaginally (P = .013), did not stay in the NICU (P < .001), had a longer gestation (P = .001), or had a higher birthweight (P = .002). In modeling atopic dermatitis with the predictor variables, only NICU length of stay remained significantly associated with a lower risk of AD (P = .004). CONCLUSION: Infants had a lower risk of developing AD if they had a longer stay in the NICU.
BACKGROUND/ OBJECTIVES: Premature infants have lower rates of atopic dermatitis (AD) compared with full-term infants, though little is known about the factors contributing to this association. We explored the infant and environmental factors that may contribute to the association between prematurity and atopic dermatitis, including mode of delivery, birthweight, gestation, and duration of stay in the neonatal intensive care unit (NICU). METHODS: This was a single-center retrospective study. Independent samples t tests or chi-square tests were used to compare groups on continuous and categorical variables, respectively. Logistic regression then examined the association of the predictor variables with AD. RESULTS: Four thousand sixteen mother-infant dyads were included. Infants had a higher risk of developing AD if they were delivered vaginally (P = .013), did not stay in the NICU (P < .001), had a longer gestation (P = .001), or had a higher birthweight (P = .002). In modeling atopic dermatitis with the predictor variables, only NICU length of stay remained significantly associated with a lower risk of AD (P = .004). CONCLUSION: Infants had a lower risk of developing AD if they had a longer stay in the NICU.
Authors: Alexander Egeberg; Yuki M F Andersen; Gunnar Gislason; Lone Skov; Jacob P Thyssen Journal: Pediatr Allergy Immunol Date: 2016-06 Impact factor: 6.377
Authors: Megan M Moore; Sheryl L Rifas-Shiman; Janet W Rich-Edwards; Ken P Kleinman; Carlos A Camargo; Diane R Gold; Scott T Weiss; Matthew W Gillman Journal: Pediatrics Date: 2004-03 Impact factor: 7.124
Authors: S Barbarot; C Gras-Leguen; H Colas; E Garrot; D Darmaun; B Larroque; J C Roze; P Y Ancel Journal: Br J Dermatol Date: 2013-12 Impact factor: 9.302
Authors: Tiffany C Scharschmidt; Kimberly S Vasquez; Hong-An Truong; Sofia V Gearty; Mariela L Pauli; Audrey Nosbaum; Iris K Gratz; Michael Otto; James J Moon; Jan Liese; Abul K Abbas; Michael A Fischbach; Michael D Rosenblum Journal: Immunity Date: 2015-11-17 Impact factor: 31.745