Kiran Sarathy1, Richard G Jung1,2,3,4, Trevor Simard1,2,3,5, Simon Parlow1, Pietro Di Santo1,2,5,6, Robert Moreland7, Young Jung8, Omar Abdel-Razek1,5, Paul Boland1, Juan J Russo1, Aun-Yeong Chong1, Derek So1, Michael Froeschl1, Alexander Dick1, Christopher Glover1, Marino Labinaz1, Michel Le May1, Benjamin Hibbert1,2,3,6. 1. Division of Cardiology, CAPITAL Research Group, University of Ottawa Heart Institute. 2. Vascular Biology and Experimental Medicine Laboratory, University of Ottawa Heart Institute. 3. Department of Cellular and Molecular Medicine, University of Ottawa. 4. School of Medicine, Faculty of Medicine, University of Ottawa. 5. Division of Cardiology, University of Ottawa Heart Institute. 6. School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada. 7. Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 8. Centre of Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario, Canada.
Abstract
BACKGROUND: Physician perception of procedural risk and clinical outcome can affect revascularization decision making. Public reporting of percutaneous coronary intervention outcomes accentuates the need for accuracy in risk prediction in order to avoid a treatment paradox of undertreating the highest risk patients. Our study compares a validated risk score to physician prediction (PP) of 1-year mortality based on clinical impression at the time of invasive angiography. METHODS AND RESULTS: We performed a cohort study between August 2015 and May 2018 to determine the discriminative accuracy of interventional cardiologists on one-year mortality of the treated patient. PP of one-year mortality was compared to the New York State Percutaneous Coronary Intervention Reporting System (NYPCIRS) score in predicting mortality. Three thousand seven hundred ninety-two patients were followed with a median follow-up period of 14.4 months (interquartile range 12.4-18.1 months) and 165 patients (4.4%) died within one-year. PP of mortality was associated with one-year mortality with a hazard ratio of 8.78 (95% confidence interval 5.24-14.71, P < 0.0001). Clinical presentation in the form of cardiogenic shock, return of spontaneous circulation, and liver and renal dysfunction were associated with PP. Diagnostic accuracy and specificity were improved in PP compared to NYPCIRS. The combination of PP to NYPCIRS improved the overall c-statistic and diagnostic yield. CONCLUSION: PP appears to be especially specific and accurate for prediction of mortality compared to NYPCIRS though it lacks sensitivity. Furthermore, the combination of PP with NYPCIRS improved the c-statistic and diagnostic yield. Overall, the utility of PP with an objective risk score improves the diagnostic accuracy of mortality prediction.
BACKGROUND: Physician perception of procedural risk and clinical outcome can affect revascularization decision making. Public reporting of percutaneous coronary intervention outcomes accentuates the need for accuracy in risk prediction in order to avoid a treatment paradox of undertreating the highest risk patients. Our study compares a validated risk score to physician prediction (PP) of 1-year mortality based on clinical impression at the time of invasive angiography. METHODS AND RESULTS: We performed a cohort study between August 2015 and May 2018 to determine the discriminative accuracy of interventional cardiologists on one-year mortality of the treated patient. PP of one-year mortality was compared to the New York State Percutaneous Coronary Intervention Reporting System (NYPCIRS) score in predicting mortality. Three thousand seven hundred ninety-two patients were followed with a median follow-up period of 14.4 months (interquartile range 12.4-18.1 months) and 165 patients (4.4%) died within one-year. PP of mortality was associated with one-year mortality with a hazard ratio of 8.78 (95% confidence interval 5.24-14.71, P < 0.0001). Clinical presentation in the form of cardiogenic shock, return of spontaneous circulation, and liver and renal dysfunction were associated with PP. Diagnostic accuracy and specificity were improved in PP compared to NYPCIRS. The combination of PP to NYPCIRS improved the overall c-statistic and diagnostic yield. CONCLUSION: PP appears to be especially specific and accurate for prediction of mortality compared to NYPCIRS though it lacks sensitivity. Furthermore, the combination of PP with NYPCIRS improved the c-statistic and diagnostic yield. Overall, the utility of PP with an objective risk score improves the diagnostic accuracy of mortality prediction.
Authors: Richard G Jung; Omar Abdel-Razek; Pietro Di Santo; Taylor Gillmore; Cameron Stotts; Dwipen Makwana; Joelle Soriano; Robert Moreland; Louis Verreault-Julien; Cheng Yee Goh; Simon Parlow; Caleb Sypkes; Daniel F Ramirez; Mouhannad Sadek; Vincent Chan; Hadi Toeg; Trevor Simard; Michael P V Froeschl; Marino Labinaz; Benjamin Hibbert Journal: Open Heart Date: 2022-09