Bernhard Wernly1, Raphael Romano Bruno2, Behrooz Mamandipoor3, Christian Jung2, Venet Osmani3. 1. Paracelsus Medical University of Salzburg, Austria, Department of Cardiology, Clinic of Internal Medicine II, Austria; Division of Cardiology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address: bernhard@wernly.at. 2. University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Medical Faculty, Division of Cardiology, Pulmonology and Vascular Medicine, Germany. 3. Fondazione Bruno Kessler Research Institute, Trento, Italy.
Abstract
BACKGROUND: Female and male critically ill septic patients might differ with regards to risk distribution, management, and outcomes. We aimed to compare male versus female septic patients in a large collective with regards to baseline risk distribution and outcomes. METHODS: In total, 17,146 patients were included in this analysis, 8781 (51%) male and 8365 (49%) female patients. The primary endpoint was ICU-mortality. Baseline characteristics and data on organ support were documented. Multilevel logistic regression analyses were used to assess sex-specific differences. RESULTS: Female patients had lower SOFA scores (5 ± 5 vs. 6 ± 6; p<0.001) and creatinine (1.20±1.35 vs. 1.40±1.54; p<0.001). In the total cohort, the ICU mortality was 10% and similar between female and male (10% vs. 10%; p = 0.34) patients. The ICU remained similar between sexes after adjustment in model-1 (aOR 1.05 95% CI 0.95-1.16; p = 0.34); model-2 (aOR 0.91 95% CI 0.79-1.05; p = 0.18) and model-3 (aOR 0.93 95% CI 0.80-1.07; p = 0.29). In sensitivity analyses, no major sex-specific differences in mortality could be detected. CONCLUSION: In this study no clinically relevant sex-specific mortality differences could be detected in critically ill septic patients. Possible subtle gender differences could play a minor role in the acute situation due to the severity of the disease in septic patients.
BACKGROUND: Female and male critically ill septicpatients might differ with regards to risk distribution, management, and outcomes. We aimed to compare male versus female septicpatients in a large collective with regards to baseline risk distribution and outcomes. METHODS: In total, 17,146 patients were included in this analysis, 8781 (51%) male and 8365 (49%) female patients. The primary endpoint was ICU-mortality. Baseline characteristics and data on organ support were documented. Multilevel logistic regression analyses were used to assess sex-specific differences. RESULTS: Female patients had lower SOFA scores (5 ± 5 vs. 6 ± 6; p<0.001) and creatinine (1.20±1.35 vs. 1.40±1.54; p<0.001). In the total cohort, the ICU mortality was 10% and similar between female and male (10% vs. 10%; p = 0.34) patients. The ICU remained similar between sexes after adjustment in model-1 (aOR 1.05 95% CI 0.95-1.16; p = 0.34); model-2 (aOR 0.91 95% CI 0.79-1.05; p = 0.18) and model-3 (aOR 0.93 95% CI 0.80-1.07; p = 0.29). In sensitivity analyses, no major sex-specific differences in mortality could be detected. CONCLUSION: In this study no clinically relevant sex-specific mortality differences could be detected in critically ill septicpatients. Possible subtle gender differences could play a minor role in the acute situation due to the severity of the disease in septicpatients.
Authors: Patricia Wischmann; Raphael Romano Bruno; Bernhard Wernly; Georg Wolff; Shazia Afzal; Richard Rezar; Mareike Cramer; Nadia Heramvand; Malte Kelm; Christian Jung Journal: Eur Heart J Open Date: 2022-06-15
Authors: Raphael Romano Bruno; Bernhard Wernly; Behrooz Mamandipoor; Richard Rezar; Stephan Binnebössel; Philipp Heinrich Baldia; Georg Wolff; Malte Kelm; Bertrand Guidet; Dylan W De Lange; Daniel Dankl; Andreas Koköfer; Thomas Danninger; Wojciech Szczeklik; Sviri Sigal; Peter Vernon van Heerden; Michael Beil; Jesper Fjølner; Susannah Leaver; Hans Flaatten; Venet Osmani; Christian Jung Journal: Front Med (Lausanne) Date: 2021-07-09
Authors: Thomas Danninger; Richard Rezar; Behrooz Mamandipoor; Daniel Dankl; Andreas Koköfer; Christian Jung; Bernhard Wernly; Venet Osmani Journal: Wien Klin Wochenschr Date: 2021-09-16 Impact factor: 1.704