| Literature DB >> 3305795 |
A Lacave, J Wils, H Bleiberg, E Diaz-Rubio, N Duez, O Dalesio.
Abstract
In a prospective phase III multicenter trial, 189 patients with advanced measurable and nonmeasurable gastric cancer were randomized to receive 5-fluorouracil (5-FU) combined with Adriamycin (FA) or FA plus methyl-CCNU (MeFA). The response rate in patients with measurable disease was 10% (three of 29), and 18% (five of 28), respectively. No difference in the duration of survival was detected (P = .14; log rank test). Median survivals were 21 and 32 weeks, respectively. Toxicity was moderate, but there have been two toxic deaths among the patients who received FA. Because of the low response rate and the short survival, neither regimen can be recommended for the treatment of advanced gastric cancer.Entities:
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Year: 1987 PMID： 3305795 DOI： 10.1200/JCO.1987.5.9.1387
Source DB: PubMed Journal: J Clin Oncol ISSN： 0732-183X Impact factor: 44.544