Shinichi Takatsuki1, Yoshiyuki Furutani2, Kei Inai2, Tohru Kobayashi3, Ryo Inuzuka4, Tomomi Uyeda5, Mitsuhiro Kamisago6, Jun Muneuchi7, Masahide Kaneko8, Yasushi Misaki8, Hiroshi Ono8, Hitoshi Kato8, Eriko Shimada2, Tokuko Shinohara2, Kenji Waki9, Kenji Suda10, Yasunobu Hayabuchi11, Hirotaka Ohki12, Reina Ishizaki13, Jun Maeda12,13, Hiroyuki Yamagishi13. 1. Department of Pediatrics, Toho University Omori Medical Center. 2. Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women's Medical University. 3. Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development. 4. Department of Pediatrics, The University of Tokyo Hospital. 5. Department of Pediatric Cardiology, Sakakibara Heart Institute. 6. Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital. 7. Department of Pediatric Cardiology, Japan Health Care Community Organization Kyushu Hospital. 8. Department of Pediatric Cardiology, National Center for Child Health and Development. 9. Department of Pediatrics, Kurashiki Central Hospital. 10. Department of Pediatrics, Kurume University Hospital. 11. Department of Pediatrics, Tokushima University Hospital. 12. Department of Cardiology, Tokyo Metropolitan Children's Medical Center. 13. Department of Pediatrics, Keio University School of Medicine.
Abstract
BACKGROUND: Although advances in cardiac surgery have led to an increased number of survivors with congenital heart disease (CHD), epidemiological data regarding the pregnancies and deliveries of patients with repaired CHD are scarce.Methods and Results: In this study, we retrospectively reviewed the clinical outcomes of pregnancies and deliveries of women with repaired CHD. Overall, 131 women with repaired CHD were enrolled and there were 269 gestations. All patients were classified as New York Heart Association (NYHA) Class I or II. The prevalence of cesarean sections was higher in patients with (CyCHD) than without (AcyCHD) a past history of cyanosis (51% vs. 19%, respectively; P<0.01). There were 228 offspring from 269 gestations and the most prevalent neonatal complication was premature birth (10%), which was more frequent in the CyCHD than AcyCHD group (15.7% vs. 5.6%, respectively; P<0.01). Five maternal cardiac complications during delivery were observed only in the CyCHD group (8%); these were classified as NYHA Class II and none was fatal. CONCLUSIONS: Delivery was successful in most women with repaired CHD who were classified as NYHA Class I or II, although some with CyCHD and NYHA Class II required more attention. Cesarean sections were more common in the CyCHD than AcyCHD group, and CyCHD may be a potential risk for preterm deliveries.
BACKGROUND: Although advances in cardiac surgery have led to an increased number of survivors with congenital heart disease (CHD), epidemiological data regarding the pregnancies and deliveries of patients with repaired CHD are scarce.Methods and Results: In this study, we retrospectively reviewed the clinical outcomes of pregnancies and deliveries of women with repaired CHD. Overall, 131 women with repaired CHD were enrolled and there were 269 gestations. All patients were classified as New York Heart Association (NYHA) Class I or II. The prevalence of cesarean sections was higher in patients with (CyCHD) than without (AcyCHD) a past history of cyanosis (51% vs. 19%, respectively; P<0.01). There were 228 offspring from 269 gestations and the most prevalent neonatal complication was premature birth (10%), which was more frequent in the CyCHD than AcyCHD group (15.7% vs. 5.6%, respectively; P<0.01). Five maternal cardiac complications during delivery were observed only in the CyCHD group (8%); these were classified as NYHA Class II and none was fatal. CONCLUSIONS: Delivery was successful in most women with repaired CHD who were classified as NYHA Class I or II, although some with CyCHD and NYHA Class II required more attention. Cesarean sections were more common in the CyCHD than AcyCHD group, and CyCHD may be a potential risk for preterm deliveries.
Authors: Yang Liu; Yanna Li; Jun Zhang; Wenjuan Zhao; Zhaoliang Bao; Xiaolong Ma; Yichen Zhao; Cheng Zhao; Kemin Liu; Qing Ye; Lixiao Su; Yao Yang; Jing Yang; Gang Li; Xiangming Fan; Jiangang Wang Journal: Front Cardiovasc Med Date: 2022-01-21