OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that causes the progressive loss of voluntary muscle control. Recent studies have reported conflicting results on alterations in resting-state functional brain networks in ALS by adopting unimodal techniques that measure either electrophysiological or vascular-hemodynamic neural functions. However, no study to date has explored simultaneous electrical and vascular-hemodynamic changes in the resting-state brain in ALS. Using complementary multimodal electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recording and analysis techniques, we explored the underlying multidimensional neural contributions to altered oscillations and functional connectivity in people with ALS. METHODS: 10 ALS patients and 9 age-matched controls underwent multimodal EEG-fNIRS recording in the resting state. Resting-state functional connectivity (RSFC) and power spectra of both modalities in both groups were analyzed and compared statistically. RESULTS: Increased fronto-parietal EEG connectivity in the alpha and beta bands and increased interhemispheric and right intra-hemispheric fNIRS connectivity in the frontal and prefrontal regions were observed in ALS. Frontal, central, and temporal theta and alpha EEG power decreased in ALS, as did parietal and occipital alpha EEG power, while frontal and parietal hemodynamic spectral power increased in ALS. SIGNIFICANCE: These results suggest that electro-vascular disruption in neuronal networks extends to the extra-motor regions in ALS patients, which can ultimately introduce novel neural markers of ALS that can be exploited further as diagnostic and prognostic tools.
OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that causes the progressive loss of voluntary muscle control. Recent studies have reported conflicting results on alterations in resting-state functional brain networks in ALS by adopting unimodal techniques that measure either electrophysiological or vascular-hemodynamic neural functions. However, no study to date has explored simultaneous electrical and vascular-hemodynamic changes in the resting-state brain in ALS. Using complementary multimodal electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recording and analysis techniques, we explored the underlying multidimensional neural contributions to altered oscillations and functional connectivity in people with ALS. METHODS: 10 ALS patients and 9 age-matched controls underwent multimodal EEG-fNIRS recording in the resting state. Resting-state functional connectivity (RSFC) and power spectra of both modalities in both groups were analyzed and compared statistically. RESULTS: Increased fronto-parietal EEG connectivity in the alpha and beta bands and increased interhemispheric and right intra-hemispheric fNIRS connectivity in the frontal and prefrontal regions were observed in ALS. Frontal, central, and temporal theta and alpha EEG power decreased in ALS, as did parietal and occipital alpha EEG power, while frontal and parietal hemodynamic spectral power increased in ALS. SIGNIFICANCE: These results suggest that electro-vascular disruption in neuronal networks extends to the extra-motor regions in ALS patients, which can ultimately introduce novel neural markers of ALS that can be exploited further as diagnostic and prognostic tools.
Authors: Stefan Dukic; Roisin McMackin; Emmet Costello; Marjorie Metzger; Teresa Buxo; Antonio Fasano; Rangariroyashe Chipika; Marta Pinto-Grau; Christina Schuster; Michaela Hammond; Mark Heverin; Amina Coffey; Michael Broderick; Parameswaran M Iyer; Kieran Mohr; Brighid Gavin; Russell McLaughlin; Niall Pender; Peter Bede; Muthuraman Muthuraman; Leonard H van den Berg; Orla Hardiman; Bahman Nasseroleslami Journal: Brain Date: 2022-04-18 Impact factor: 15.255