Literature DB >> 33054382

Developing drugs for the 'undruggable'.

Abigail Sawyer1.   

Abstract

There are up to 650,000 'undruggable' protein-protein interactions (PPIs) in the human interactome that can be potentially considered as novel therapeutic targets. How does the 'undruggable' become 'druggable'?

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Year:  2020        PMID： 33054382     DOI： 10.2144/btn-2020-0134

Source DB:  PubMed          Journal:  Biotechniques        ISSN： 0736-6205            Impact factor:   1.993


  2 in total

Review 1.  Recent advancements in the discovery of cereblon-based protease-targeted chimeras with potential for therapeutic intervention.

Authors:  Harbinder Singh; Devendra K Agrawal
Journal:  Future Med Chem       Date:  2022-09-01       Impact factor: 4.767

2.  A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury.

Authors:  Nir Qvit; Amanda J Lin; Aly Elezaby; Nicolai P Ostberg; Juliane C Campos; Julio C B Ferreira; Daria Mochly-Rosen
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-22
  2 in total

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