Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations.

Literature DB >> 33052773

Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations.

Cory W Baumann¹, Dongmin Kwak^2,3, LaDora V Thompson³.

Abstract

The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human frailty assessments were reverse-translated to mice. Here, we highlight the development of the mouse frailty phenotype, unique discoveries, experimental considerations, and future perspectives.

Entities: Species

Keywords: aging; function; index; physiology; resilience

Year: 2020 PMID： 33052773 PMCID： PMC7864238 DOI： 10.1152/physiol.00016.2020

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

63 in total

1. Battery of behavioral tests in mice that models age-associated changes in human motor function.

Authors: Jamie N Justice; Christy S Carter; Hannah J Beck; Rachel A Gioscia-Ryan; Matthew McQueen; Roger M Enoka; Douglas R Seals
Journal: Age (Dordr) Date: 2014-04

Review 2. Loneliness and social isolation as risk factors for mortality: a meta-analytic review.

Authors: Julianne Holt-Lunstad; Timothy B Smith; Mark Baker; Tyler Harris; David Stephenson
Journal: Perspect Psychol Sci Date: 2015-03

3. The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies.

Authors: Caroline S Blaum; Qian Li Xue; Elisabete Michelon; Richard D Semba; Linda P Fried
Journal: J Am Geriatr Soc Date: 2005-06 Impact factor: 5.562

Review 4. Prevalence of frailty in community-dwelling older persons: a systematic review.

Authors: Rose M Collard; Han Boter; Robert A Schoevers; Richard C Oude Voshaar
Journal: J Am Geriatr Soc Date: 2012-08-06 Impact factor: 5.562

5. Frailty Quantified by the "Valencia Score" as a Potential Predictor of Lifespan in Mice.

Authors: Irene Martinez de Toda; Antonio Garrido; Carmen Vida; Mari Carmen Gomez-Cabrera; Jose Viña; Monica De la Fuente
Journal: J Gerontol A Biol Sci Med Sci Date: 2018-09-11 Impact factor: 6.053

6. Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice.

Authors: Sherry A Said; Rachel Isedowo; Christilynn Guerin; Navreek N Nar; Leesa Lillie; Shawn Bukovac; Jonathan J Simone; Matthew R Green; Cheryl M McCormick; Jeffrey A Stuart
Journal: Geroscience Date: 2018-08-11 Impact factor: 7.713

Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations.

1. Battery of behavioral tests in mice that models age-associated changes in human motor function.

Review 2. Loneliness and social isolation as risk factors for mortality: a meta-analytic review.

3. The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies.

Review 4. Prevalence of frailty in community-dwelling older persons: a systematic review.

5. Frailty Quantified by the "Valencia Score" as a Potential Predictor of Lifespan in Mice.

6. Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice.

Review 7. Animal models of frailty: current applications in clinical research.

8. Identifying Characteristics of Frailty in Female Mice Using a Phenotype Assessment Tool.

9. Sublethal whole-body irradiation causes progressive premature frailty in mice.

10. Accumulation of deficits as a proxy measure of aging.

Review 1. Physiological Systems in Promoting Frailty.