Literature DB >> 33052772

Multi-Level Regulation of Opioid-Induced Respiratory Depression.

Barbara Palkovic1,2, Vitaliy Marchenko1, Edward J Zuperku1,3, Eckehard A E Stuth1,4, Astrid G Stucke1,4.   

Abstract

Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well as from depression of the Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive to preBötzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.

Entities:  

Keywords:  Parabrachial Nucleus/Kölliker-Fuse Complex; awake drive; chemodrive; opioids; preBötzinger Complex

Year:  2020        PMID： 33052772      PMCID： PMC7864237          DOI： 10.1152/physiol.00015.2020

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  168 in total

1.  Pre-Bötzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons.

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Journal:  J Comp Neurol       Date:  2012-04-01       Impact factor: 3.215

2.  Opioid-induced Respiratory Depression Is Only Partially Mediated by the preBötzinger Complex in Young and Adult Rabbits In Vivo.

Authors:  Astrid G Stucke; Justin R Miller; Ivana Prkic; Edward J Zuperku; Francis A Hopp; Eckehard A E Stuth
Journal:  Anesthesiology       Date:  2015-06       Impact factor: 7.892

3.  Lack of positive interaction between CO2 and hypoxic stimulation for P(CO2)-VAS response slope in humans.

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Journal:  Respir Physiol       Date:  2001-07

4.  Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate.

Authors:  Angela A Navarrete-Opazo; Denise R Cook-Snyder; Justin R Miller; Jennifer J Callison; Nicole McCarthy; Barbara Palkovic; Eckehard A E Stuth; Edward J Zuperku; Astrid G Stucke
Journal:  Respir Physiol Neurobiol       Date:  2020-02-06       Impact factor: 1.931

5.  Fentanyl shock: The changing geography of overdose in the United States.

Authors:  Michael Zoorob
Journal:  Int J Drug Policy       Date:  2019-05-09

6.  Opioid action on respiratory neuron activity of the isolated respiratory network in newborn rats.

Authors:  S Takeda; L I Eriksson; Y Yamamoto; H Joensen; H Onimaru; S G Lindahl
Journal:  Anesthesiology       Date:  2001-09       Impact factor: 7.892

7.  Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

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Journal:  J Neurosci       Date:  2011-09-07       Impact factor: 6.167

8.  D1-dopamine receptor agonists prevent and reverse opiate depression of breathing but not antinociception in the cat.

Authors:  Peter M Lalley
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2005-02-10       Impact factor: 3.619

9.  Evidence for the emergence of an opioid-resistant respiratory rhythm following fentanyl overdose.

Authors:  Philippe Haouzi; Nicholas Mellen; Marissa McCann; Molly Sternick; Daniel Guck; Nicole Tubbs
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10.  The mu opioid receptor modulates neurotransmission in the rat spinal ventral horn.

Authors:  Hiroyuki Honda; Yasuhiko Kawasaki; Hiroshi Baba; Tatsuro Kohno
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  9 in total

1.  Contribution of the caudal medullary raphe to opioid induced respiratory depression.

Authors:  Barbara Palkovic; Denise Cook-Snyder; Jennifer J Callison; Thomas M Langer; Riley Nugent; Eckehard A E Stuth; Edward J Zuperku; Astrid G Stucke
Journal:  Respir Physiol Neurobiol       Date:  2022-02-03       Impact factor: 1.931

2.  The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine.

Authors:  Rob Hill; Andrew C Kruegel; Jonathan A Javitch; J Robert Lane; Meritxell Canals
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3.  Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia.

Authors:  Michael W Jenkins; Faiza Khalid; Santhosh M Baby; Walter J May; Alex P Young; James N Bates; Feixiong Cheng; James M Seckler; Stephen J Lewis
Journal:  Sci Rep       Date:  2021-03-26       Impact factor: 4.379

4.  Mu-opioid receptor-dependent transformation of respiratory motor pattern in neonates in vitro.

Authors:  Maia G Gumnit; Jyoti J Watters; Tracy L Baker; Sarah M Johnson; Stephen M Johnson
Journal:  Front Physiol       Date:  2022-07-22       Impact factor: 4.755

5.  Nucleus Tractus Solitarius Neurons Activated by Hypercapnia and Hypoxia Lack Mu Opioid Receptor Expression.

Authors:  Sebastian N Maletz; Brandon T Reid; Adrienn G Varga; Erica S Levitt
Journal:  Front Mol Neurosci       Date:  2022-07-11       Impact factor: 6.261

6.  Current research in pathophysiology of opioid-induced respiratory depression, neonatal opioid withdrawal syndrome, and neonatal antidepressant exposure syndrome.

Authors:  Brian A Baldo
Journal:  Curr Res Toxicol       Date:  2022-06-06

7.  L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats.

Authors:  Paulina M Getsy; Santhosh M Baby; Walter J May; James N Bates; Christopher R Ellis; Michael G Feasel; Christopher G Wilson; Tristan H J Lewis; Benjamin Gaston; Yee-Hsee Hsieh; Stephen J Lewis
Journal:  Front Pharmacol       Date:  2022-09-28       Impact factor: 5.988

8.  Acute morphine blocks spinal respiratory motor plasticity via long-latency mechanisms that require toll-like receptor 4 signalling.

Authors:  Arash Tadjalli; Yasin B Seven; Abhisheak Sharma; Christopher R McCurdy; Donald C Bolser; Erica S Levitt; Gordon S Mitchell
Journal:  J Physiol       Date:  2021-07-06       Impact factor: 6.228

9.  Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kölliker-Fuse Complex and Pre-Bötzinger Complex.

Authors:  Barbara Palkovic; Jennifer J Callison; Vitaliy Marchenko; Eckehard A E Stuth; Edward J Zuperku; Astrid G Stucke
Journal:  Anesthesiology       Date:  2021-10-01       Impact factor: 8.986
  9 in total

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