| Literature DB >> 33052681 |
Pablo Pertejo1, Beatriz González-Saiz1, Roberto Quesada1, María García-Valverde1.
Abstract
A simple one-pot protocol for the synthesis of fused pyrrolopiperazines with a complete diastereoselectivity has been developed. This novel methodology combined the Ugi reaction with a spontaneous enamine alkylation on a multicomponent domino reaction, starting from nonprotected diamines and arylglyoxals.Entities:
Year: 2020 PMID： 33052681 DOI： 10.1021/acs.joc.0c02103
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354