Ting Liu1,2, Na Li1, Zongjie Hou1, Linsheng Liu3, Lihong Gao3, Lin Wang4, Jiying Tan5. 1. Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation and Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, Gansu, China. 2. Department of Geriatrics, The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China. 3. Tianshui Changkon Hospital, Tianshui, 741000, Gansu, China. 4. Department of General Practice (Department of Geriatrics Ward 4), The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China. 5. Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation and Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, Gansu, China. jiyingtan@yahoo.com.
Abstract
OBJECTIVE: To evaluate the effect of nutrition combined physical exercise interventions on age-related cognitive decline by a systematic review and meta-analysis. METHODS: We searched 9 databases, including PubMed, EMbase, The Cochrane Library, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI), VIP Information, China Biological Medical Database (CBM) and Wanfang for studies published until the end of December 2019. The selected trials should meet the following criteria, study objects: healthy adults aged 65 and over with cognitive dysfunction or diagnosed as MCI, but not meet the diagnostic criteria for dementia as well as no restriction on follow-up time, race or gender. Study interventions: multiple interventions including nutrition and exercise. EXCLUSION CRITERIA: (1) studies included elderly people with any type of dementia or patients with cognitive impairment induced by secondary causes, including drug, alcohol, severe organic brain diseases, mental disorders. (2) Republished literature. (3) Studies with significant differences in baseline data between groups. (4) The data in the study cannot be converted into the required data format. We reviewed and extracted information and assessed the risk of bias of recruited studies independently. Meta-analysis was performed using STATA v.15.1 software. The bias of publication was estimated by Egger test. RESULTS: A total of six RCTs representing 1039 participates were included in our meta-analysis. In terms of global cognitive function that has been assessed by neuropsychological test in different combinations, the result showed that the beneficial effect of nutrition combined exercise interventions was statistically significant [SMD = 0.23, 95% CI (0.1, 0.36), P = 0.0004]. There were no statistical differences from assays on MMSE scores, Memory, Executive Function, Attention, and Information Processing Speed across groups. CONCLUSIONS: The current study shows that nutrition combined exercise interventions can improve global cognitive function in the aged with cognitive decline. Further researches emphasizing on longer follow-up time, experimental randomness, credibility and scale would better elucidate the effect of nutrition combined exercise interventions on cognitive function, particularly in older adults. (registration number: CRD42020159291, date of registration: 28/04/2020).
OBJECTIVE: To evaluate the effect of nutrition combined physical exercise interventions on age-related cognitive decline by a systematic review and meta-analysis. METHODS: We searched 9 databases, including PubMed, EMbase, The Cochrane Library, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI), VIP Information, China Biological Medical Database (CBM) and Wanfang for studies published until the end of December 2019. The selected trials should meet the following criteria, study objects: healthy adults aged 65 and over with cognitive dysfunction or diagnosed as MCI, but not meet the diagnostic criteria for dementia as well as no restriction on follow-up time, race or gender. Study interventions: multiple interventions including nutrition and exercise. EXCLUSION CRITERIA: (1) studies included elderly people with any type of dementia or patients with cognitive impairment induced by secondary causes, including drug, alcohol, severe organic brain diseases, mental disorders. (2) Republished literature. (3) Studies with significant differences in baseline data between groups. (4) The data in the study cannot be converted into the required data format. We reviewed and extracted information and assessed the risk of bias of recruited studies independently. Meta-analysis was performed using STATA v.15.1 software. The bias of publication was estimated by Egger test. RESULTS: A total of six RCTs representing 1039 participates were included in our meta-analysis. In terms of global cognitive function that has been assessed by neuropsychological test in different combinations, the result showed that the beneficial effect of nutrition combined exercise interventions was statistically significant [SMD = 0.23, 95% CI (0.1, 0.36), P = 0.0004]. There were no statistical differences from assays on MMSE scores, Memory, Executive Function, Attention, and Information Processing Speed across groups. CONCLUSIONS: The current study shows that nutrition combined exercise interventions can improve global cognitive function in the aged with cognitive decline. Further researches emphasizing on longer follow-up time, experimental randomness, credibility and scale would better elucidate the effect of nutrition combined exercise interventions on cognitive function, particularly in older adults. (registration number: CRD42020159291, date of registration: 28/04/2020).
Authors: Tze Pin Ng; Ling Hui Audrey Ling; Liang Feng; Ma Shwe Zin Nyunt; Lei Feng; Mathew Niti; Boon Yeow Tan; Gribson Chan; Sue Anne Khoo; Sue Mei Chan; Philip Yap; Keng Bee Yap Journal: J Gerontol A Biol Sci Med Sci Date: 2018-05-09 Impact factor: 6.053
Authors: James A Blumenthal; Patrick J Smith; Stephanie Mabe; Alan Hinderliter; Pao-Hwa Lin; Lawrence Liao; Kathleen A Welsh-Bohmer; Jeffrey N Browndyke; William E Kraus; P Murali Doraiswamy; James R Burke; Andrew Sherwood Journal: Neurology Date: 2018-12-19 Impact factor: 11.800
Authors: Annelien C van den Brink; Elske M Brouwer-Brolsma; Agnes A M Berendsen; Ondine van de Rest Journal: Adv Nutr Date: 2019-11-01 Impact factor: 8.701
Authors: Kelly Parker; Brenda Vincent; Yeong Rhee; Bong-Jin Choi; Sheria G Robinson-Lane; Jeremy M Hamm; Lukus Klawitter; Donald A Jurivich; Ryan McGrath Journal: Aging Clin Exp Res Date: 2021-09-15 Impact factor: 3.636