FBP-Net for direct reconstruction of dynamic PET images.

Dynamic positron emission tomography (PET) imaging can provide information about metabolic changes over time, used for kinetic analysis and auxiliary diagnosis. Existing deep learning-based reconstruction methods have too many trainable parameters and poor generalization, and require mass data to train the neural network. However, obtaining large amounts of medical data is expensive and time-consuming. To reduce the need for data and improve the generalization of network, we combined the filtered back-projection (FBP) algorithm with neural network, and proposed FBP-Net which could directly reconstruct PET images from sinograms instead of post-processing the rough reconstruction images obtained by traditional methods. The FBP-Net contained two parts: the FBP part and the denoiser part. The FBP part adaptively learned the frequency filter to realize the transformation from the detector domain to the image domain, and normalized the coarse reconstruction images obtained. The denoiser part merged the information of all time frames to improve the quality of dynamic PET reconstruction images, especially the early time frames. The proposed FBP-Net was performed on simulation and real dataset, and the results were compared with the state-of-art U-net and DeepPET. The results showed that FBP-Net did not tend to overfit the training set and had a stronger generalization. Creative Commons Attribution license.