Myocardial injury associated with coronavirus disease 2019 in pregnancy.

Objective

The coronavirus disease 2019 (COVID-19) is associated with cardiac injury1, 2, 3 and bradycardia in the nonpregnant population. The incidence of these complications in pregnancy is unknown. The objective of this study was to determine the rate of abnormal serum cardiac biomarkers or bradycardia among pregnant and immediately postpartum women admitted for treatment of severe or critical COVID-19 in a large integrated health system in New York.

Study Design

This is a retrospective review of all pregnant and immediately postpartum women hospitalized for COVID-19 at 7 hospitals within Northwell Health, the largest academic health system in the state of New York, from March 1, 2020, to April 30, 2020. Women who tested positive for severe acute respiratory syndrome coronavirus 2 by polymerase chain reaction (PCR) assay and who met the National Institute of Health criteria for severe or critical illness were included. Women with a positive PCR test who were admitted for a reason other than treatment of COVID-19 (eg, labor) were excluded. The Northwell Health Institutional Review Board approved the study as minimal-risk research using data collected for routine clinical practice and waived the requirement for informed consent.

Clinical records were manually reviewed. Data collected included demographics, medical comorbidities, pregnancy characteristics, laboratory and imaging results, medications administered, and clinical outcomes. Laboratory and imaging studies were ordered at the discretion of the attending physician. The primary outcomes evaluated were elevated cardiac troponins (I, T, or high sensitivity), elevated brain natriuretic peptide (BNP), bradycardia (defined as <60 bpm), and maternal heart rate (HR) nadir. Descriptive statistics were used to characterize the data.

Results

A total of 31 women met the inclusion criteria; among those women, 20 (65%) had cardiac biomarkers measured during hospitalization (Table ). Cardiac troponins and BNP were elevated in 4 of 18 (22%) and 3 of 10 (30%) of these patients, respectively. Furthermore, 4 patients had transthoracic echocardiograms performed, and all were reported as normal. No patient had preexisting cardiovascular disease or hypertension. Of note, 2 maternal mortalities in this cohort were previously reported; both patients had elevated cardiac troponins, and 1 also had an elevated BNP.

Table

Characteristics of patients with normal and abnormal cardiac markers

Characteristic	Patients with normal cardiac biomarkers (n=13)	Patients with elevated cardiac biomarkers (n=7)
Maternal age (y)	33.0±4.4	32.0±4.5
≥35 y	2 (15.4)	3 (42.9)
Race or ethnicity
White	5 (38.5)	2 (28.5)
African American	2 (15.4)	0
Hispanic	6 (42.8)	0
Asian	0	3 (42.8)
Other, unknown, or multiracial	0	2 (28.5)
Multiparous	9 (69.2)	7 (100)
Parity of 3 or more	3 (23.1)	2 (28.5)
BMI prepregnancy (kg/m2)	34.7±6.7	32.5±6.0
≥30 kg/m2	8 (61.5)	5 (71.4)
Medical comorbidities
Hypertension	0	0
Diabetes	0	1 (14.3)
Asthma	1 (7.7)	1 (14.3)
Preexisting cardiac disease	0	0
Pregnancy complications
Gestational diabetes	1 (7.7)	0
Gestational hypertension or preeclampsia	3 (23.1)	2 (28.5)
COVID-19
Gestational age at hospitalization (wk)	33.5 (10.8)	34.5 (4.5) (1 postpartum)
Reported symptoms
Fever, subjective or measured	9 (69.2)	6 (85.7)
Cough	8 (61.5)	6 (85.7)
Dyspnea	9 (69.2)	6 (85.7)
Nausea or diarrhea	1 (7.7)	1 (14.3)
Other	0	1 (14.3) (abdominal pain)
Medications
Hydroxychloroquine	11 (84.6)	3 (42.8)
Corticosteroids	5 (38.5)	4 (57.1)
Remdesivir	0	2 (28.5)
Interleukin inhibitors	1 (7.7)	3 (42.8)
Convalescent plasma	0	1 (14.3)
Vital signs
Temperature, ≥100.4°F or 38.0°C	6 (42.8)	5 (71.4)
Max HR, >100 bpm	10 (76.9)	6 (85.7)
Min HR, <60 bpm	6 (42.8)	3 (42.8)
Respiratory rate, >30 bpm	4 (30.7)	4 (57.1)
Oxygen saturation (min), %	87.8±6.2	84.6±10.2
≤93%	11 (84.6)	5 (71.4)
Biomarkers
BNP, >300 pg/mL	0	4 (57.1)
hs-Trop, >6–14 ng/L	0	1 (14.3)
Troponin T, >0.06 ng/mL	0	1 (14.3)
Troponin I, >0.045 ng/mL	0	2 (28.5)
Echocardiogram	1 (7.7)	3 (42.8)
Number of d admitted to hospital	8 (11.0)	4 (9.0)
Intensive care unit admission	5 (38.5)	6 (85.7)
Maternal mortality	0	2 (28.5)

Data are presented as number (percentage), median (interquartile range), or mean±standard deviation unless otherwise specified.

Reference ranges: high sensitivity cardiac troponins, <6–14 ng/L; troponin T, 0.00–0.06 ng/mL; troponin I, 0.000–0.045; BNP, <300 pg/mL.

BMI, body mass index; BNP, brain natriuretic peptide; COVID-19, coronavirus disease 2019; HR, heart rate; Max, maximum; Min, minimum.

Shetty. Myocardial injury associated with coronavirus disease 2019. Am J Obstet Gynecol 2021.

The nadir HR ranged from 30 to 92 bpm, and bradycardia occurred in 10 of 31 patients (one-third). Half of the women with elevated troponin and three-fourths of the women with elevated BNP had an episode of bradycardia recorded during their hospital course.

Conclusion

Myocardial injury as demonstrated by abnormal cardiac biomarkers and bradycardia may be common among pregnant women with severe or critical COVID-19. In this study, one-fifth of the patients who had troponin levels measured were found to have elevations (one-eighth of the overall study population). Among patients who had BNP levels measured, 30% were elevated (10% of the overall study population). One-third of the women had bradycardia.

This study is limited by a small sample size. Laboratory testing and imaging were not uniform because of the retrospective nature of the study. Sampling bias was unavoidable because the decision to measure cardiac markers or perform imaging studies was made by the patient’s care team, based on clinical presentation rather than a formal protocol.

Few studies have evaluated the risk of cardiac injury or arrhythmia among pregnant women with COVID-19. It is also unknown whether there are long-term sequelae that affect maternal health or future pregnancy outcomes. This is an important area of focus for future research.