Babak Sayad1, Zohreh Rahimi2,3. 1. Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran. 2. Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran. 3. Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
Abstract
BACKGROUND: Infection with coronavirus disease 2019 (COVID-19) could be complicated with coagulopathy and high risk of thromboembolic events. AIMS: The main aim of the present study was to find the coagulation profile of intensive care unit (ICU) admitted patients with COVID-19 from Kermanshah, Islamic Republic of Iran. METHODS: Coagulation parameters were analyzed using appropriate methods in 74 patients (24 patients aged <60 years and 50 patients ≥60 years) and were compared with 35 survivors (severe COVID-19) and 39 non-survivors (severe COVID-19) historically admitted to the ICU. RESULTS: Forty-two percent of patients had abnormal prothrombin time and international normalized ratio. The rates of mortality and comorbidity in patients aged ≥ 60 years were 73.7% and 78.4% compared to 26.3% and 21.6%, respectively, in patients aged < 60 years. CONCLUSION: We found an abnormal pattern of coagulation parameters and association of advanced age and comorbidities with a high rate of mortality in severe COVID-19 patients, which should be taken into consideration in their hospital management.
BACKGROUND: Infection with coronavirus disease 2019 (COVID-19) could be complicated with coagulopathy and high risk of thromboembolic events. AIMS: The main aim of the present study was to find the coagulation profile of intensive care unit (ICU) admitted patients with COVID-19 from Kermanshah, Islamic Republic of Iran. METHODS: Coagulation parameters were analyzed using appropriate methods in 74 patients (24 patients aged <60 years and 50 patients ≥60 years) and were compared with 35 survivors (severe COVID-19) and 39 non-survivors (severe COVID-19) historically admitted to the ICU. RESULTS: Forty-two percent of patients had abnormal prothrombin time and international normalized ratio. The rates of mortality and comorbidity in patients aged ≥ 60 years were 73.7% and 78.4% compared to 26.3% and 21.6%, respectively, in patients aged < 60 years. CONCLUSION: We found an abnormal pattern of coagulation parameters and association of advanced age and comorbidities with a high rate of mortality in severe COVID-19 patients, which should be taken into consideration in their hospital management.
Authors: Abrahão Fontes Baptista; Adriana Baltar; Alexandre Hideki Okano; Alexandre Moreira; Ana Carolina Pinheiro Campos; Ana Mércia Fernandes; André Russowsky Brunoni; Bashar W Badran; Clarice Tanaka; Daniel Ciampi de Andrade; Daniel Gomes da Silva Machado; Edgard Morya; Eduardo Trujillo; Jaiti K Swami; Joan A Camprodon; Katia Monte-Silva; Katia Nunes Sá; Isadora Nunes; Juliana Barbosa Goulardins; Marom Bikson; Pedro Sudbrack-Oliveira; Priscila de Carvalho; Rafael Jardim Duarte-Moreira; Rosana Lima Pagano; Samuel Katsuyuki Shinjo; Yossi Zana Journal: Front Neurol Date: 2020-11-25 Impact factor: 4.003