Literature DB >> 3304735

The detection and characterization of renal brush border antigen (gp108) in various rat tissues.

Y Natori, I Hayakawa, S Shibata.   

Abstract

We recently reported that an injection of antibody raised against renal brush border glycoprotein, gp108, in rats induced passive Heymann nephritis with acute and severe proteinuria. In this study, the distribution of gp108 in various rat tissues was investigated. On enzyme immunoassay, anti-gp108 antibody reacted to extracts of small intestine, lung, spleen, thymus, liver, epididymis, stomach, pancreas and heart. It also reacted to sera and extracts of peripheral blood cells, especially lymphocytes. These antigens, which are cross-reactive to kidney gp108 have similar biochemical properties: a molecular weight of about 108,000 and an isoelectric point of 4.8-5.4. These results show that immunologically and biochemically related antigens to renal glycoprotein, gp108, are present in various rat tissues.

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Year:  1987        PMID： 3304735      PMCID： PMC1542551     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  14 in total

1.  The organ distribution of gp-330 (Heymann antigen) and gp-90 in the mouse and the rat.

Authors:  K J Assmann; W P Lange; M M Tangelder; R A Koene
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1986

2.  Passive transfer of Heymann nephritis with serum.

Authors:  T Sugisaki; J Klassen; G A Andres; F Milgrom; R T McCluskey
Journal:  Kidney Int       Date:  1973-02       Impact factor: 10.612

3.  Characterization and isolation of specific renal tubular epithelial antigens.

Authors:  T S Edgington; R J Glassock; J I Watson; F J Dixon
Journal:  J Immunol       Date:  1967-12       Impact factor: 5.422

4.  Nephritogenic and non-nephritogenic epithelial antigens in autoimmune and passive Heymann nephritis.

Authors:  A Miettinen; T Törnroth; P Ekblom; I Virtanen; E Linder
Journal:  Lab Invest       Date:  1984-04       Impact factor: 5.662

5.  An immunopathologic study of a 330-kD protein defined by monoclonal antibodies and reactive with anti-RTE alpha 5 antibodies and kidney eluates from active Heymann nephritis.

Authors:  P Ronco; T J Neale; C B Wilson; M Galceran; P Verroust
Journal:  J Immunol       Date:  1986-01       Impact factor: 5.422

6.  A monoclonal antibody to brush border and passive Heymann nephritis.

Authors:  P Ronco; L Allegri; C Melcion; E Pirotsky; M D Appay; J Bariety; F Pontillon; P Verroust
Journal:  Clin Exp Immunol       Date:  1984-02       Impact factor: 4.330

7.  The pathogenesis of experimental membranous glomerulonephritis induced with homologous nephritogenic tubular antigen.

Authors:  T Naruse; T Fukasawa; N Hirokawa; S Oike; Y Miyakawa
Journal:  J Exp Med       Date:  1976-11-02       Impact factor: 14.307

8.  Characterization of the antigen (gp600) of Heymann nephritis.

Authors:  S P Makker; A K Singh
Journal:  Lab Invest       Date:  1984-03       Impact factor: 5.662

9.  Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.

Authors:  W HEYMANN; D B HACKEL; S HARWOOD; S G WILSON; J L HUNTER
Journal:  Proc Soc Exp Biol Med       Date:  1959-04

10.  Autologous immune complex nephritis induced with renal tubular antigen. I. Identification and isolation of the pathogenetic antigen.

Authors:  T S Edgington; R J Glassock; F J Dixon
Journal:  J Exp Med       Date:  1968-03-01       Impact factor: 14.307
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  4 in total

1.  Role of dipeptidyl peptidase IV (gp 108) in passive Heymann nephritis. Use of dipeptidyl peptidase IV-deficient rats.

Authors:  Y Natorio; I Hayakawa; S Shibata
Journal:  Am J Pathol       Date:  1989-02       Impact factor: 4.307

2.  Formation of subepithelial dense deposits in rats induced by a monoclonal antibody against the glomerular cell surface antigen.

Authors:  K Nishikawa; A Fukatsu; H Tamai; N Suzuki; Y Ito; N Sakamoto; S Matsuo
Journal:  Clin Exp Immunol       Date:  1991-01       Impact factor: 4.330

3.  Identification of gp108, a pathogenic antigen of passive Heymann nephritis, as dipeptidyl peptidase IV.

Authors:  Y Natori; I Hayakawa; S Shibata
Journal:  Clin Exp Immunol       Date:  1987-11       Impact factor: 4.330

4.  Proteinuria induced by anti-dipeptidyl peptidase IV (gp108); role of circulating and glomerular antigen.

Authors:  Y Natori; N Shindo; Y Natori
Journal:  Clin Exp Immunol       Date:  1994-02       Impact factor: 4.330
  4 in total

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