Literature DB >> 3304732

Antihypertensive action of melatonin in the spontaneously hypertensive rat.

K Kawashima, Y Miwa, K Fujimoto, H Oohata, H Nishino, H Koike.   

Abstract

The effects of melatonin on blood pressure and heart rate were studied in 23-week-old male spontaneously hypertensive rats. Melatonin infused i.p. at a dose of 6 mg/rat per day for 5 days using an osmotic minipump produced a significant reduction of blood pressure and a slight but significant decrease of heart rate in the conscious and unrestrained state. These cardiovascular effects of melatonin developed gradually. Plasma renin concentration tended to decrease after melatonin treatment. These results demonstrate that melatonin has an antihypertensive action. The mechanism of the antihypertensive action of melatonin requires further study.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3304732     DOI： 10.3109/10641968709160037

Source DB:  PubMed          Journal:  Clin Exp Hypertens A        ISSN： 0730-0077


  13 in total

Review 1.  Melatonin membrane receptors in peripheral tissues: distribution and functions.

Authors:  Radomir M Slominski; Russel J Reiter; Natalia Schlabritz-Loutsevitch; Rennolds S Ostrom; Andrzej T Slominski
Journal:  Mol Cell Endocrinol       Date:  2012-01-08       Impact factor: 4.102

Review 2.  Disturbed tryptophan metabolism in cardiovascular disease.

Authors:  H Mangge; I Stelzer; E Z Reininghaus; D Weghuber; T T Postolache; D Fuchs
Journal:  Curr Med Chem       Date:  2014-06       Impact factor: 4.530

3.  Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study.

Authors:  P Lusardi; E Piazza; R Fogari
Journal:  Br J Clin Pharmacol       Date:  2000-05       Impact factor: 4.335

Review 4.  Clinical relevance of about-yearly changes in blood pressure and the environment.

Authors:  F Halberg; G Cornélissen; E Haus; G Northrup; A Portela; H Wendt; K Otsuka; Y Kumagai; Y Watanabe; R Zaslavskaya
Journal:  Int J Biometeorol       Date:  1996-11       Impact factor: 3.787

5.  Effects of continuous light and melatonin treatment on energy metabolism of the rat.

Authors:  A M Mustonen; P Nieminen; H Hyvärinen
Journal:  J Endocrinol Invest       Date:  2002-09       Impact factor: 4.256

6.  Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans.

Authors:  Chester A Ray
Journal:  J Physiol       Date:  2003-07-17       Impact factor: 5.182

7.  Dose-dependent dual effect of melatonin on ototoxicity induced by amikacin in adult rats.

Authors:  Tamer Erdem; Orhan Ozturan; Mustafa Iraz; Murat Cem Miman; Ercument Olmez
Journal:  Eur Arch Otorhinolaryngol       Date:  2004-05-28       Impact factor: 2.503

Review 8.  Role of melatonin in metabolic regulation.

Authors:  Ahmet Korkmaz; Turgut Topal; Dun-Xian Tan; Russel J Reiter
Journal:  Rev Endocr Metab Disord       Date:  2009-12       Impact factor: 6.514

9.  Aerobic exercise enhanced endothelium-dependent vasorelaxation in mesenteric arteries in spontaneously hypertensive rats: the role of melatonin.

Authors:  Fang Qiu; Xiaodong Liu; Yanyan Zhang; Ying Wu; Daliao Xiao; Lijun Shi
Journal:  Hypertens Res       Date:  2018-07-02       Impact factor: 3.872

10.  Melatonin does not attenuate dynamic cardiovascular and cerebrovascular reflex responses to acute hypotension in healthy men.

Authors:  Jiyoun Bang; Yong Seok Park; Sung-Moon Jeong; Jun-Gol Song; Young-Kug Kim; Gyu-Sam Hwang
Journal:  Korean J Anesthesiol       Date:  2012-09-14
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.