William T Berg1, Martin Miner2. 1. Department of Urology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York. 2. Warren Alpert School of Medicine, Brown University, Providence, Rhode Islands, USA.
Abstract
PURPOSE OF REVIEW: The prevalence of metabolic syndrome and hypogonadism continues to rise in the United States and around the world. These two conditions are inexorably linked, and understanding their relationship with each other is key to treating men with either of these conditions. RECENT FINDINGS: Testosterone has been shown to be a key regulator in the maintenance of metabolic homeostasis. A large volume of research has found that testosterone deficiency is closely linked to metabolic syndrome through complex physiologic mechanisms of endothelial dysfunction, inflammation, and glucose metabolism. SUMMARY: Interventions through lifestyle modification and testosterone replacement in hypogonadal men may reduce the morbidity and mortality risks associated with metabolic syndrome.
PURPOSE OF REVIEW: The prevalence of metabolic syndrome and hypogonadism continues to rise in the United States and around the world. These two conditions are inexorably linked, and understanding their relationship with each other is key to treating men with either of these conditions. RECENT FINDINGS:Testosterone has been shown to be a key regulator in the maintenance of metabolic homeostasis. A large volume of research has found that testosterone deficiency is closely linked to metabolic syndrome through complex physiologic mechanisms of endothelial dysfunction, inflammation, and glucose metabolism. SUMMARY: Interventions through lifestyle modification and testosterone replacement in hypogonadal men may reduce the morbidity and mortality risks associated with metabolic syndrome.
Authors: Marja G J Veugen; Veronica G Onete; Ronald M A Henry; Hans-Peter Brunner-La Rocca; Annemarie Koster; Pieter C Dagnelie; Nicolaas C Schaper; Simone J S Sep; Carla J H van der Kallen; Martin P J van Boxtel; Koen D Reesink; Johannes S Schouten; Hans H C M Savelberg; Sebastian Köhler; Frans R Verhey; Joop P W van den Bergh; Miranda T Schram; Coen D A Stehouwer Journal: Sci Rep Date: 2022-05-05 Impact factor: 4.996