Magda Tsolaki1,2, Eftychia Lazarou2, Mahi Kozori2, Niki Petridou2, Irene Tabakis1, Ioulietta Lazarou1, Maria Karakota2, Iordanis Saoulidis1, Eleni Melliou3, Prokopios Magiatis3. 1. Department of Neurology General University Hopsital "AHEPA", Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Makedonia, Greece. 2. Greek Association of Alzheimer's Disease and Related Disorders, Thessaloniki, Makedonia, Greece. 3. Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, Greece.
Abstract
BACKGROUND:Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function. OBJECTIVE: To investigate for the first time the effect of Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EH-EVOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) in people with mild cognitive impairment (MCI). METHODS: We conducted a randomized prospective study so as to examine the HP-EH-EVOO and MP-EVOO versus MeDi in MCI. Genetic predisposition (APOEɛ4) to Alzheimer's disease (AD) was tested and an extensive neuropsychological battery was administered at baseline and after 12 months. Each participant was randomized and assigned one of three groups: 1) Group 1 received the HP-EH-EVOO (50 mL/day); 2) Group 2 received the MP-EVOO (50 mL/day), and 3) Group 3 received only the MeDi instructions. RESULTS: Better follow-up performance was found in Group 1 compared to Group 2 and Group 3 in the almost all cognitive domains. Moreover, Group 2 showed also significant improvement compared to Group 3 in ADAS-cog (p = 0.001) and MMSE (p = 0.05), whereas Group 3 exhibited worse or similar to baseline performance in almost all domains. In particular, Group 1 and Group 2 had better outcomes with regards to ADAS-cog (p = 0.003), Digit Span (p = 0.006), and Letter fluency (p = 0.003). Moreover, there was a significant difference (p = 0.001) in the presence of APOEɛ4 between the Groups 1 and 2 versus Group 3. CONCLUSION: Long-term intervention with HP-EH-EVOO or MP-EVOO was associated with significant improvement in cognitive function compared to MeDi, independent of the presence of APOEɛ4.
RCT Entities:
BACKGROUND: Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function. OBJECTIVE: To investigate for the first time the effect of Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EH-EVOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) in people with mild cognitive impairment (MCI). METHODS: We conducted a randomized prospective study so as to examine the HP-EH-EVOO and MP-EVOO versus MeDi in MCI. Genetic predisposition (APOEɛ4) to Alzheimer's disease (AD) was tested and an extensive neuropsychological battery was administered at baseline and after 12 months. Each participant was randomized and assigned one of three groups: 1) Group 1 received the HP-EH-EVOO (50 mL/day); 2) Group 2 received the MP-EVOO (50 mL/day), and 3) Group 3 received only the MeDi instructions. RESULTS: Better follow-up performance was found in Group 1 compared to Group 2 and Group 3 in the almost all cognitive domains. Moreover, Group 2 showed also significant improvement compared to Group 3 in ADAS-cog (p = 0.001) and MMSE (p = 0.05), whereas Group 3 exhibited worse or similar to baseline performance in almost all domains. In particular, Group 1 and Group 2 had better outcomes with regards to ADAS-cog (p = 0.003), Digit Span (p = 0.006), and Letter fluency (p = 0.003). Moreover, there was a significant difference (p = 0.001) in the presence of APOEɛ4 between the Groups 1 and 2 versus Group 3. CONCLUSION: Long-term intervention with HP-EH-EVOO or MP-EVOO was associated with significant improvement in cognitive function compared to MeDi, independent of the presence of APOEɛ4.
Authors: Marta Guasch-Ferré; Yanping Li; Walter C Willett; Qi Sun; Laura Sampson; Jordi Salas-Salvadó; Miguel A Martínez-González; Meir J Stampfer; Frank B Hu Journal: J Am Coll Cardiol Date: 2022-01-18 Impact factor: 24.094
Authors: Laura Torres-Collado; Manuela García-de la Hera; Carla Lopes; Laura María Compañ-Gabucio; Alejandro Oncina-Cánovas; Leyre Notario-Barandiaran; Sandra González-Palacios; Jesús Vioque Journal: Front Nutr Date: 2022-08-30