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Literature DB >> 33043967

Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19.

Marina Rieder^1,2, Luisa Wirth³, Luisa Pollmeier³, Maren Jeserich^1,2, Isabella Goller^1,2, Niklas Baldus^1,2, Bonaventura Schmid⁴, Hans-Joerg Busch⁴, Maike Hofmann⁵, Winfried Kern⁶, Christoph Bode^1,2, Daniel Duerschmied^1,2, Achim Lother^1,2,3.

Abstract

BACKGROUND: The role of the renin-angiotensin-aldosterone system (RAAS) in coronavirus disease 2019 (COVID-19) is controversially discussed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells by binding to angiotensin-converting enzyme 2 (ACE2) and activity of the RAAS may affect susceptibility to SARS-CoV-2 infection and outcome of patients with COVID-19.
METHODS: In this prospective single-center study, we determined the serum levels of ACE2, angiotensin II, and aldosterone in patients with COVID-19 compared with control patients presenting with similar symptoms in the emergency unit.
RESULTS: We analyzed serum samples from 24 SARS-CoV-2 positive and 61 SARS-CoV-2 negative patients. SARS-CoV-2 positive and control patients did not differ in baseline patients characteristics, symptoms, and clinical presentation. Mean serum concentrations of ACE2, angiotensin II, and aldosterone did not differ between the SARS-CoV-2 positive and the control group. In line with this, serum potassium as surrogate parameter for RAAS activity and blood pressure were similar in both groups.
CONCLUSIONS: In summary, we did not find evidence for altered RAAS activity including angiotensin II, aldosterone, or potassium levels, and blood pressure in patients with COVID-19. CLINICAL TRIALS REGISTRATION: Trial Number DRKS00021206. © American Journal of Hypertension, Ltd 2020. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities: Chemical Disease Gene Species

Keywords: ACE2; COVID-19; SARS-CoV-2; aldosterone; angiotensin II; blood pressure; hypertension

Mesh：

Substances：

Year: 2021 PMID： 33043967 PMCID： PMC7665331 DOI： 10.1093/ajh/hpaa169

Source DB: PubMed Journal: Am J Hypertens ISSN： 0895-7061 Impact factor: 2.689

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Cited

23 in total

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2. Unquantifiably low aldosterone concentrations are prevalent in hospitalised COVID-19 patients but may not be revealed by chemiluminescent immunoassay.

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Journal: Front Cardiovasc Med Date: 2022-06-24

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Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19.

1. Expression of ACE2 in the Intact and Acutely Injured Kidney.

2. Unquantifiably low aldosterone concentrations are prevalent in hospitalised COVID-19 patients but may not be revealed by chemiluminescent immunoassay.

3. Plasma Angiotensin II Is Increased in Critical Coronavirus Disease 2019.

4. Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19.

5. Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2.

6. ICODE: the international COVID-19 thrombosis biomarkers colloquium-novel soluble biomarkers: circulating cell-free nucleic acids and other molecules.

Review 7. ACE2-based decoy receptors for SARS coronavirus 2.

8. Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice.

Review 9. Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19.

Review 10. The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?