A Mechanochromic Hydrogen-Bonded Rotaxane.

Tensile forces influence a variety of important biological processes and force sensors are required to study these processes in vivo. Current force sensors are often tailor-made for a specific application, or activate at much higher forces than those observed at the cellular or tissue level. A versatile force sensor, with tunable mechanical and optical properties, activated at low pN forces will be ideal. In this communication, a new mechanoresponsive fluorescent hydrogen-bonded rotaxane, built around a maleimide dye, is reported. Its force-sensing properties are demonstrated in a polyacrylamide gel, a synthetic model of living tissue.