Maria Teresa Pellecchia1, Iva Stankovic2, Alessandra Fanciulli3, Florian Krismer3, Wassilios G Meissner4, Jose-Alberto Palma5, Jalesh N Panicker6,7, Klaus Seppi3, Gregor K Wenning3. 1. Center for Neurodegenerative Diseases, Department of Medicine, Neuroscience Section, University of Salerno Fisciano Italy. 2. Neurology Clinic, Clinical Center of Serbia School of Medicine, University of Belgrade Belgrade Serbia. 3. Department of Neurology Innsbruck Medical University Innsbruck Austria. 4. French Reference Center for MSA, Department of Neurology University Hospital Bordeaux, Bordeaux and Institute of Neurodegenerative Disorders, University Bordeaux, Centre National de la Recherche Scientifique Unite Mixte de Recherche Bordeaux Bordeaux France. 5. Dysautonomia Center, Langone Medical Center New York University School of Medicine New York New York USA. 6. Institute of Neurology, University College London London United Kingdom. 7. Department of Uro-Neurology The National Hospital for Neurology and Neurosurgery London United Kingdom.
Abstract
BACKGROUND: In the current consensus diagnostic criteria, the diagnosis of probable multiple system atrophy (MSA) is based solely on clinical findings, whereas neuroimaging findings are listed as aid for the diagnosis of possible MSA. There are overlapping phenotypes between MSA-parkinsonian type and Parkinson's disease, progressive supranuclear palsy, and dementia with Lewy bodies, and between MSA-cerebellar type and sporadic adult-onset ataxia resulting in a significant diagnostic delay and misdiagnosis of MSA during life. OBJECTIVES: In light of an ongoing effort to revise the current consensus criteria for MSA, the Movement Disorders Society Multiple System Atrophy Study Group performed a systematic review of original articles published before August 2019. METHODS: We included articles that studied at least 10 patients with MSA as well as participants with another disorder or control group for comparison purposes. MSA was defined by neuropathological confirmation, or as clinically probable, or clinically probable plus possible according to consensus diagnostic criteria. RESULTS: We discuss the pitfalls and benefits of each diagnostic test and provide specific recommendations on how to evaluate patients in whom MSA is suspected. CONCLUSIONS: This systematic review of relevant studies indicates that imaging and autonomic function tests significantly contribute to increasing the accuracy of a diagnosis of MSA.
BACKGROUND: In the current consensus diagnostic criteria, the diagnosis of probable multiple system atrophy (MSA) is based solely on clinical findings, whereas neuroimaging findings are listed as aid for the diagnosis of possible MSA. There are overlapping phenotypes between MSA-parkinsonian type and Parkinson's disease, progressive supranuclear palsy, and dementia with Lewy bodies, and between MSA-cerebellar type and sporadic adult-onset ataxia resulting in a significant diagnostic delay and misdiagnosis of MSA during life. OBJECTIVES: In light of an ongoing effort to revise the current consensus criteria for MSA, the Movement Disorders Society Multiple System Atrophy Study Group performed a systematic review of original articles published before August 2019. METHODS: We included articles that studied at least 10 patients with MSA as well as participants with another disorder or control group for comparison purposes. MSA was defined by neuropathological confirmation, or as clinically probable, or clinically probable plus possible according to consensus diagnostic criteria. RESULTS: We discuss the pitfalls and benefits of each diagnostic test and provide specific recommendations on how to evaluate patients in whom MSA is suspected. CONCLUSIONS: This systematic review of relevant studies indicates that imaging and autonomic function tests significantly contribute to increasing the accuracy of a diagnosis of MSA.
Authors: Mathias Schreckenberger; Stefan Hägele; Thomas Siessmeier; Hans-Georg Buchholz; Heike Armbrust-Henrich; Frank Rösch; Gerhard Gründer; Peter Bartenstein; Thomas Vogt Journal: Eur J Nucl Med Mol Imaging Date: 2004-03-23 Impact factor: 9.236
Authors: Iva Stankovic; Alessandra Fanciulli; Vladimir S Kostic; Florian Krismer; Wassilios G Meissner; Jose Alberto Palma; Jalesh N Panicker; Klaus Seppi; Gregor K Wenning Journal: Mov Disord Clin Pract Date: 2021-03-10
Authors: Suman Dutta; Simon Hornung; Adira Kruayatidee; Katherine N Maina; Irish Del Rosario; Kimberly C Paul; Darice Y Wong; Aline Duarte Folle; Daniela Markovic; Jose-Alberto Palma; Geidy E Serrano; Charles H Adler; Susan L Perlman; Wayne W Poon; Un Jung Kang; Roy N Alcalay; Miriam Sklerov; Karen H Gylys; Horacio Kaufmann; Brent L Fogel; Jeff M Bronstein; Beate Ritz; Gal Bitan Journal: Acta Neuropathol Date: 2021-05-15 Impact factor: 15.887