Saloni Arora 1 , Smriti Prasad 1 , Akshatha Sharma 1 , Anita Kaul 1 Show Affiliations »
Abstract
BACKGROUND: This study aimed to evaluate the usefulness of the first-trimester crown-rump length (CRL) and nuchal translucency (NT) discordance in monochorionic diamniotic twins (MCDA) for the prediction of complications-twin-twin transfusion syndrome (TTTS), selective fetal growth restriction (sFGR) or intrauterine fetal demise (IUFD). METHODS: Intertwin discordance in the CRL and NT was calculated as a percentage of the larger CRL and NT, respectively. The performance of inter twin discordance (CRL ≥ 10% and NT≥ 20%) for predicting complications was analysed using standard statistical screening test methods. RESULTS: Fifty-eight MCDA twin pregnancies were studied. Out of them, 19 (32%) pregnancies resulted in one of the complications studied (4 TTTS, 10 sFGR, 5 IUFD). CRL and NT discordance showed an increased probability of developing complications positive likelihood ratio (LR+) {95% confidence interval}: 2.05 {0.46-9.23} and 1.88 {1.03-3.45}, respectively. NT discordance showed a sensitivity of 57%. CONCLUSIONS: Although discordant first-trimester CRL and NT in monochorionic twins are poor screening tools for early prediction, if positive, they increase the risk of developing complications. © Federation of Obstetric & Gynecological Societies of India 2020.
BACKGROUND: This study aimed to evaluate the usefulness of the first-trimester crown-rump length (CRL) and nuchal translucency (NT) discordance in monochorionic diamniotic twins (MCDA) for the prediction of complications-twin-twin transfusion syndrome (TTTS), selective fetal growth restriction (sFGR) or intrauterine fetal demise (IUFD). METHODS: Intertwin discordance in the CRL and NT was calculated as a percentage of the larger CRL and NT, respectively. The performance of inter twin discordance (CRL ≥ 10% and NT≥ 20%) for predicting complications was analysed using standard statistical screening test methods. RESULTS: Fifty-eight MCDA twin pregnancies were studied. Out of them, 19 (32%) pregnancies resulted in one of the complications studied (4 TTTS, 10 sFGR, 5 IUFD). CRL and NT discordance showed an increased probability of developing complications positive likelihood ratio (LR+) {95% confidence interval}: 2.05 {0.46-9.23} and 1.88 {1.03-3.45}, respectively. NT discordance showed a sensitivity of 57%. CONCLUSIONS: Although discordant first-trimester CRL and NT in monochorionic twins are poor screening tools for early prediction, if positive, they increase the risk of developing complications. © Federation of Obstetric & Gynecological Societies of India 2020.
Entities: Chemical
Keywords:
CRL discordance; First-trimester screening; MCDA twins; NT discordance
Year: 2020
PMID： 33041551 PMCID： PMC7515990 DOI： 10.1007/s13224-020-01354-0
Source DB: PubMed Journal: J Obstet Gynaecol India ISSN： 0975-6434