Constantine Alifrangis1, Anand Sharma2, Shafi Chowdhury3, Sarah Duncan3, Marina Milic2, Andrew Gogbashian4, Samita Agarwal5, Anju Sahdev6, Peter Wilson3, Stephen Harland7, Sara Stoneham7, Michelle Lockley8, Gordon Rustin2, Timothy Oliver3, Daniel Berney9, Jonathan Shamash10. 1. University College London Hospitals NHS Trust, NW1 2BU, UK; Department of Medical Oncology, St Bartholomew's Hospital, London, EC1A 7BE, UK. 2. Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, HA6 2RN, UK. 3. Department of Medical Oncology, St Bartholomew's Hospital, London, EC1A 7BE, UK. 4. Department of Radiology, Mount Vernon Cancer Centre, Paul Strickland Scanner Centre, Northwood, HA6 2RN, UK. 5. Department of Histopathology, East and North Herts NHS Trust, Lister Hospital Stevenage, SG1 4AB, UK. 6. Department of Radiology, St Bartholomew's Hospital, London, EC1A 7BE, UK. 7. University College London Hospitals NHS Trust, NW1 2BU, UK. 8. University College London Hospitals NHS Trust, NW1 2BU, UK; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, UK. 9. Department of Histopathology, St Bartholomew's Hospital, London, EC1A 7BE, UK. 10. Department of Medical Oncology, St Bartholomew's Hospital, London, EC1A 7BE, UK. Electronic address: Jonathan.shamash2@nhs.net.
Abstract
BACKGROUND: Radiotherapy and cisplatin-based combination chemotherapy are accepted standard-of-care treatments for metastatic seminoma with excellent survival outcomes but with established short- and long-term morbidity. Carboplatin monotherapy may be a less toxic alternative; however early historic studies at AUC7 showed inferior outcomes. OBJECTIVES: To evaluate multi-institutional data on and toxicity and longer-term survival for metastatic seminoma patients treated with the single-agent carboplatin AUC10. METHODS: We undertook a multi-institutional analysis incorporating all men with the International Germ Cell Cancer Collaborative Group good-prognosis metastatic seminoma treated until 2018. Carboplatin AUC10 was given every 21 days. Toxicity, progression-free survival (PFS), disease-specific survival (DSS) and overall survival were noted. Variables predictive of progression were identified. RESULTS AND LIMITATIONS: 216 patients were treated. The three-year PFS rate was 96.5%, and five-year DSS was 98.3%. There were seven relapses, of which 5 were successfully salvaged with further chemotherapy ± surgery, and three non-seminoma-related deaths. There were no treatment-related deaths. Of 148/216 evaluable patients for toxicity, 37% and 27% suffered >/ = grade III neutropenia and thrombocytopenia, respectively. Twelve percent of patients needed a platelet or blood transfusion (or both). The incidence of febrile neutropenia was 5%. CONCLUSION: For metastatic seminoma, carboplatin AUC10 harbours a similar oncological efficacy to established therapies, with a low failure risk. The major acute toxicity was myelosuppression. Our study establishes carboplatin AUC10 as another standard-of-care treatment option for good-prognosis metastatic seminoma, with a potentially lower toxicity profile than other therapies.
BACKGROUND: Radiotherapy and cisplatin-based combination chemotherapy are accepted standard-of-care treatments for metastatic seminoma with excellent survival outcomes but with established short- and long-term morbidity. Carboplatin monotherapy may be a less toxic alternative; however early historic studies at AUC7 showed inferior outcomes. OBJECTIVES: To evaluate multi-institutional data on and toxicity and longer-term survival for metastatic seminoma patients treated with the single-agent carboplatin AUC10. METHODS: We undertook a multi-institutional analysis incorporating all men with the International Germ Cell Cancer Collaborative Group good-prognosis metastatic seminoma treated until 2018. Carboplatin AUC10 was given every 21 days. Toxicity, progression-free survival (PFS), disease-specific survival (DSS) and overall survival were noted. Variables predictive of progression were identified. RESULTS AND LIMITATIONS: 216 patients were treated. The three-year PFS rate was 96.5%, and five-year DSS was 98.3%. There were seven relapses, of which 5 were successfully salvaged with further chemotherapy ± surgery, and three non-seminoma-related deaths. There were no treatment-related deaths. Of 148/216 evaluable patients for toxicity, 37% and 27% suffered >/ = grade III neutropenia and thrombocytopenia, respectively. Twelve percent of patients needed a platelet or blood transfusion (or both). The incidence of febrile neutropenia was 5%. CONCLUSION: For metastatic seminoma, carboplatin AUC10 harbours a similar oncological efficacy to established therapies, with a low failure risk. The major acute toxicity was myelosuppression. Our study establishes carboplatin AUC10 as another standard-of-care treatment option for good-prognosis metastatic seminoma, with a potentially lower toxicity profile than other therapies.
Authors: M Mego; D Svetlovska; M Reckova; K Kalavska; J Obertova; P Palacka; K Rejlekova; Z Sycova-Mila; M Chovanec; J Mardiak Journal: Invest New Drugs Date: 2021-05-29 Impact factor: 3.850
Authors: Matthew J Murray; Rafael Moleron; Jennifer Adamski; Martin English; G A Amos Burke; Justin Cross; Thankamma Ajithkumar; Sara Stoneham; James C Nicholson Journal: Pediatr Blood Cancer Date: 2021-09-14 Impact factor: 3.167