Deep eutectic solvent-based dispersive liquid-liquid micro-extraction of pesticides in food samples.

Deep eutectic solvents are versatile, green and new generation solvents that can be used during dispersive liquid-liquid micro-extraction techniques for pesticides. They have tunable physico-chemical properties that can be easily changed by varying the ratios of hydrogen bond donors and hydrogen bond acceptors in their structures. Deep eutectic solvents are non-flammable, chemically and thermally stable solvents with low vapour pressure. Thus, they have characteristics that are similar to those of ionic liquids. However, they have simpler synthetic procedures, less expensive and are more biodegradable than ionic liquids. One of the limitations of deep eutectic solvents is their toxicity to the environment but they are less toxic than ionic liquids. This paper gives a focused and comprehensive recent review on the applications of deep eutectic solvents during dispersive liquid-liquid micro-extraction of pesticides in food samples for the period starting from 2016 to 2020. Emphasis was placed on the modifications done to the deep eutectic solvent-based dispersive liquid-liquid micro-extraction techniques in order to enhance their greenness during pesticide pre-concentration in food samples. In addition, hyphenated dispersive liquid-liquid micro-extraction techniques were also reviewed and lastly, the paper outlined the challenges associated with the use of DESs during the DLLME techniques.