M E Foeller1, C Nosrat2, A Krystosik3, T Noel4,5, P Gérardin6,7, N Cudjoe4, V Mapp-Alexander4,5, G Mitchell8, C Macpherson4,5, R Waechter4,5, A D LaBeaud3. 1. Department of Obstetrics and Gynecology, Stanford University, Stanford, CA, USA. 2. Program in Human Biology, Stanford University, Stanford, CA, USA. 3. Division of Infectious Disease, Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA, USA. 4. Windward Islands Research and Education Foundation, True Blue, Grenada. 5. St. George's University, St. Georges, Grenada. 6. INSERM CIC1410, Centre Hospitalier Universitaire de la Réunion, Saint Pierre, Réunion. 7. Unité Mixte 134 PIMIT (INSERM 1187, CNRS 9192, IRD 249, Université de La Réunion), Sainte Clotilde, Réunion. 8. Ministry of Health, St. Georges, Grenada.
Abstract
OBJECTIVE: To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV). DESIGN: Retrospective observational study. SETTING: Grenada. POPULATION: Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible. METHODS: This descriptive study investigated 731 mother-infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA. MAIN OUTCOME MEASURES: Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity. RESULTS: Of 416 mother-infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P < 0.0001). Rates of pregnancy complications (RR = 0.76, P = 0.599), intrapartum complications (RR = 1.50, P = 0.633), and neonatal outcomes were otherwise similar. Possible mother-to-child transmission occurred in two (1.3%) mother-infant pairs and two of eight intrapartum infections (25%). CONCLUSION: CHIKV infection during pregnancy may be protective against long-term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother-to-child transmission of CHIKV. TWEETABLE ABSTRACT: Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.
OBJECTIVE: To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV). DESIGN: Retrospective observational study. SETTING: Grenada. POPULATION: Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible. METHODS: This descriptive study investigated 731 mother-infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA. MAIN OUTCOME MEASURES: Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity. RESULTS: Of 416 mother-infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P < 0.0001). Rates of pregnancy complications (RR = 0.76, P = 0.599), intrapartum complications (RR = 1.50, P = 0.633), and neonatal outcomes were otherwise similar. Possible mother-to-child transmission occurred in two (1.3%) mother-infant pairs and two of eight intrapartum infections (25%). CONCLUSION: CHIKV infection during pregnancy may be protective against long-term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother-to-child transmission of CHIKV. TWEETABLE ABSTRACT: Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.
Authors: P Grivard; K Le Roux; P Laurent; A Fianu; J Perrau; J Gigan; G Hoarau; N Grondin; F Staikowsky; F Favier; A Michault Journal: Pathol Biol (Paris) Date: 2007-10-24
Authors: Patrick Gérardin; Georges Barau; Alain Michault; Marc Bintner; Hanitra Randrianaivo; Ghassan Choker; Yann Lenglet; Yasmina Touret; Anne Bouveret; Philippe Grivard; Karin Le Roux; Séverine Blanc; Isabelle Schuffenecker; Thérèse Couderc; Fernando Arenzana-Seisdedos; Marc Lecuit; Pierre-Yves Robillard Journal: PLoS Med Date: 2008-03-18 Impact factor: 11.069
Authors: Pius S Ekong; Mabel K Aworh; Elysse N Grossi-Soyster; Yiltawe S Wungak; Nanven A Maurice; Jonathan Altamirano; Michael J Ekong; Babasola O Olugasa; Chika I Nwosuh; David Shamaki; Bonto Faburay; Desiree A LaBeaud Journal: Pathogens Date: 2022-07-04