Yang Wang1, Wei Wang2,3, Jianming Yao4, Lianghua Chen2, Shaolei Yi5,6. 1. Department of Radiation Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China. 2. Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China. 3. Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, 324 Jingwulu, Jinan, 250010, Shandong Province, China. 4. Department of Cardiology, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan, China. 5. Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China. leisci@163.com. 6. Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, 324 Jingwulu, Jinan, 250010, Shandong Province, China. leisci@163.com.
Abstract
OBJECTIVES: It is imperative to understand the influence of second-generation cryoballoon (CB-2) and contact-force sensing radiofrequency ablation (CF-RF) on clinical outcomes in atrial fibrillation (AF). This updated meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of CB-2 vs. CF-RF in patients with AF. METHODS: RCTs on the use of CB-2 vs. CF-RF in patients with AF were included. The primary outcome was the recurrence of AF, and the key secondary outcomes included serious complications, acute pulmonary vein isolation (PVI), procedure duration, and fluoroscopy time. RESULTS: A total of 261 articles were identified, and five studies with a total of 845 participants were included in the study. A total of 93% of participants had paroxysmal AF, 7% of participants had persistent AF, and none of participants had permanent AF. There were 499 participants in the CB-2 arm and 346 in the CF-RF arm. AF recurrence was comparable in the CB-2 group (30.3%) and the CF-RF group (29.2%) (OR = 0.93; 95%CI = 0.56-1.54; P = 0.79; I2 = 48%). There were no statistical differences in acute PVI (P = 0.92; I2 = 0%) and serious complications (P = 0.87; I2 = 47%) between the two groups. The procedure duration was shorter in the CB-2 group than in the CF-RF group (MD = - 13.39; 95%CI = - 15.58, - 7.19; P < 0.0001; I2 = 59%). CONCLUSION: Our study demonstrated that CB-2 and CF-RF had comparable recurrences of AF and similar incidences of serious complications in AF patients during the ablation process.
OBJECTIVES: It is imperative to understand the influence of second-generation cryoballoon (CB-2) and contact-force sensing radiofrequency ablation (CF-RF) on clinical outcomes in atrial fibrillation (AF). This updated meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of CB-2 vs. CF-RF in patients with AF. METHODS: RCTs on the use of CB-2 vs. CF-RF in patients with AF were included. The primary outcome was the recurrence of AF, and the key secondary outcomes included serious complications, acute pulmonary vein isolation (PVI), procedure duration, and fluoroscopy time. RESULTS: A total of 261 articles were identified, and five studies with a total of 845 participants were included in the study. A total of 93% of participants had paroxysmal AF, 7% of participants had persistent AF, and none of participants had permanent AF. There were 499 participants in the CB-2 arm and 346 in the CF-RF arm. AF recurrence was comparable in the CB-2 group (30.3%) and the CF-RF group (29.2%) (OR = 0.93; 95%CI = 0.56-1.54; P = 0.79; I2 = 48%). There were no statistical differences in acute PVI (P = 0.92; I2 = 0%) and serious complications (P = 0.87; I2 = 47%) between the two groups. The procedure duration was shorter in the CB-2 group than in the CF-RF group (MD = - 13.39; 95%CI = - 15.58, - 7.19; P < 0.0001; I2 = 59%). CONCLUSION: Our study demonstrated that CB-2 and CF-RF had comparable recurrences of AF and similar incidences of serious complications in AFpatients during the ablation process.
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