Xinfeng Zhou1, Yijian Zhang1, Yun Teng1, Angela Carley Chen2, Tao Liu3, Huilin Yang1, Fan He4. 1. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China; Orthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China. 2. School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario NZL 3G1, Canada. 3. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China. 4. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China; Orthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China. Electronic address: fanhe@suda.edu.cn.
Abstract
BACKGROUND: The present study aimed to summarize the predictors of acute kidney injury (AKI) in patients after hip surgery. METHODS: A literature search was performed using PubMed, EMBASE, Cochrane Library, and Web of Science for studies assessing the predictors of AKI after hip fracture surgery. Pooled odds ratio (OR) and mean difference (MD) of those who experienced AKI compared to those who did not were calculated for each variable. Evidence was assessed using the Newcastle-Ottawa Scale. RESULTS: Ten studies with 34 potential factors were included in the meta-analysis. In the primary analysis, 12 factors were associated with AKI, comprising males (OR 1.25; 95% confidence interval (CI) 1.14-1.36), advanced age (MD 2.28; 95% CI 0.80-3.75), myocardial infarction (OR 1.39; 95% CI 1.18-1.63), hypertension (OR 1.46; 95% CI 1.13-1.89), diabetes (OR 1.84; 95% CI 1.40-2.42), chronic kidney disease (OR 3.66; 95% CI 2.21-6.07), hip arthroplasty (OR 1.35; 95% CI 1.22-1.50), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers use (OR 2.28; 95% CI 1.68-3.08), more intraoperative blood loss (MD 44.06; 95% CI 2.88-85.24), higher preoperative blood urea nitrogen levels (MD 5.29; 95% CI 3.38-7.20), higher preoperative serum creatinine levels (MD 0.4; 95% CI 0.26-0.53), and lower preoperative estimated glomerular filtration rate (MD -19.59; 95% CI -26.92--12.26). Another 13 factors related to AKI in individual studies were identified in the systematic review. CONCLUSION: Related prophylaxis strategies should be implemented in patients involved with the above-mentioned characteristics to prevent AKI after hip surgery.
BACKGROUND: The present study aimed to summarize the predictors of acute kidney injury (AKI) in patients after hip surgery. METHODS: A literature search was performed using PubMed, EMBASE, Cochrane Library, and Web of Science for studies assessing the predictors of AKI after hip fracture surgery. Pooled odds ratio (OR) and mean difference (MD) of those who experienced AKI compared to those who did not were calculated for each variable. Evidence was assessed using the Newcastle-Ottawa Scale. RESULTS: Ten studies with 34 potential factors were included in the meta-analysis. In the primary analysis, 12 factors were associated with AKI, comprising males (OR 1.25; 95% confidence interval (CI) 1.14-1.36), advanced age (MD 2.28; 95% CI 0.80-3.75), myocardial infarction (OR 1.39; 95% CI 1.18-1.63), hypertension (OR 1.46; 95% CI 1.13-1.89), diabetes (OR 1.84; 95% CI 1.40-2.42), chronic kidney disease (OR 3.66; 95% CI 2.21-6.07), hip arthroplasty (OR 1.35; 95% CI 1.22-1.50), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers use (OR 2.28; 95% CI 1.68-3.08), more intraoperative blood loss (MD 44.06; 95% CI 2.88-85.24), higher preoperative blood ureanitrogen levels (MD 5.29; 95% CI 3.38-7.20), higher preoperative serum creatinine levels (MD 0.4; 95% CI 0.26-0.53), and lower preoperative estimated glomerular filtration rate (MD -19.59; 95% CI -26.92--12.26). Another 13 factors related to AKI in individual studies were identified in the systematic review. CONCLUSION: Related prophylaxis strategies should be implemented in patients involved with the above-mentioned characteristics to prevent AKI after hip surgery.
Authors: Amit X Garg; Meaghan Cuerden; Hector Aguado; Mohammed Amir; Emilie P Belley-Cote; Keyur Bhatt; Bruce M Biccard; Flavia K Borges; Matthew Chan; David Conen; Emmanuelle Duceppe; Sergey Efremov; John Eikelboom; Edith Fleischmann; Landoni Giovanni; Peter Gross; Raja Jayaram; Mikhail Kirov; Ydo Kleinlugtenbelt; Andrea Kurz; Andre Lamy; Kate Leslie; Valery Likhvantsev; Vladimir Lomivorotov; Maura Marcucci; Maria José Martínez-Zapata; Michael McGillion; William McIntyre; Christian Meyhoff; Sandra Ofori; Thomas Painter; Pilar Paniagua; Chirag Parikh; Joel Parlow; Ameen Patel; Carisi Polanczyk; Toby Richards; Pavel Roshanov; Denis Schmartz; Daniel Sessler; Tim Short; Jessica M Sontrop; Jessica Spence; Sadeesh Srinathan; David Stillo; Wojciech Szczeklik; Vikas Tandon; David Torres; Thomas Van Helder; Jessica Vincent; C Y Wang; Michael Wang; Richard Whitlock; Maria Wittmann; Denis Xavier; P J Devereaux Journal: Can J Kidney Health Dis Date: 2022-01-07