Literature DB >> 33037976

How is information transmitted in a nerve?

Michel Peyrard1.   

Abstract

In the last 15 years, a debate has emerged about the validity of the famous Hodgkin-Huxley model for nerve impulse. Mechanical models have been proposed. This note reviews the experimental properties of the nerve impulse and discusses the proposed alternatives. The experimental data, which rule out some of the alternative suggestions, show that while the Hodgkin-Huxley model may not be complete, it nevertheless includes essential features that should not be overlooked in the attempts made to improve, or supersede, it.

Keywords:  Axon; Hodgkin-Huxley model; Nerve cell; Nerve impulse

Year:  2020        PMID: 33037976      PMCID: PMC7719126          DOI: 10.1007/s10867-020-09557-2

Source DB:  PubMed          Journal:  J Biol Phys        ISSN: 0092-0606            Impact factor:   1.365


  42 in total

1.  Discontinuous volume transitions in ionic gels and their possible involvement in the nerve excitation process.

Authors:  I Tasaki; P M Byrne
Journal:  Biopolymers       Date:  1992-08       Impact factor: 2.505

2.  Computation of impulse initiation and saltatory conduction in a myelinated nerve fiber.

Authors:  R FITZHUGH
Journal:  Biophys J       Date:  1962-01       Impact factor: 4.033

3.  Mechanism of voltage gating in potassium channels.

Authors:  Morten Ø Jensen; Vishwanath Jogini; David W Borhani; Abba E Leffler; Ron O Dror; David E Shaw
Journal:  Science       Date:  2012-04-13       Impact factor: 47.728

4.  A brief historical perspective: Hodgkin and Huxley.

Authors:  Christof J Schwiening
Journal:  J Physiol       Date:  2012-06-01       Impact factor: 5.182

5.  Julius Bernstein (1839-1917): pioneer neurobiologist and biophysicist.

Authors:  Ernst-August Seyfarth
Journal:  Biol Cybern       Date:  2005-12-08       Impact factor: 2.086

6.  Resting and action potentials in single nerve fibres.

Authors:  A L Hodgkin; A F Huxley
Journal:  J Physiol       Date:  1945-10-15       Impact factor: 5.182

7.  The important consequences of the reversible heat production in nerves and the adiabaticity of the action potential.

Authors:  Thomas Heimburg
Journal:  Prog Biophys Mol Biol       Date:  2020-08-14       Impact factor: 3.667

8.  Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons.

Authors:  Ke Xu; Guisheng Zhong; Xiaowei Zhuang
Journal:  Science       Date:  2012-12-13       Impact factor: 47.728

Review 9.  Playing the devil's advocate: is the Hodgkin-Huxley model useful?

Authors:  Claude Meunier; Idan Segev
Journal:  Trends Neurosci       Date:  2002-11       Impact factor: 13.837

10.  Studies on the mechanism of general anesthesia.

Authors:  Mahmud Arif Pavel; E Nicholas Petersen; Hao Wang; Richard A Lerner; Scott B Hansen
Journal:  Proc Natl Acad Sci U S A       Date:  2020-05-28       Impact factor: 11.205

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