Toshihisa Murofushi1, Masahito Tsubota2, Yasuhisa Kanai3, Hideho Endo3, Munetaka Ushio4. 1. Department of Otolaryngology, Teikyo University School of Medicine Mizonokuchi Hospital, 5-1-1 Futago, Takatsu-ku, Kawasaki, 213-8507, Japan. toshi-tky@umin.ac.jp. 2. Department of Otolaryngology, Teikyo University School of Medicine Mizonokuchi Hospital, 5-1-1 Futago, Takatsu-ku, Kawasaki, 213-8507, Japan. 3. Department of Radiology, Ochanomizu Surugadai Clinic, Tokyo, Japan. 4. Department of Otolaryngology, Toho University School of Medicine Sakura Medical Center, Sakura, Japan.
Abstract
PURPOSE: To examine the concordance between cervical vestibular-evoked myogenic potential (cVEMP) tuning property test results and MRI findings of endolymphatic hydrops (EH). METHODS: Fourteen subjects (age 24-76 years) that had been diagnosed with unilateral definite Meniere's disease (MD) (N = 8) or unilateral probable MD (N = 6) were enrolled. All of the subjects underwent cVEMP tests (using 500 Hz and 1000 Hz tone bursts), pure-tone audiometry, and gadolinium-enhanced 3 T-MRI. To examine tuning properties of cVEMP, the 500-1000 Hz amplitude ratio was calculated as the SLOPE. The results of the cVEMP tuning property test results were compared with EH-related MRI findings. RESULTS: EH positivity in both the cochlea and vestibule on MRI was observed in 7 of the 8 affected ears of definite MD and 3 of the 6 affected ears of probable MD, although it was only in one of the 14 unaffected ears. EH(+) or no response (NR) in cVEMP tuning property test was significantly associated with EH positivity on MRI, while EH(-) in the cVEMP tuning property test was significantly associated with EH-negativity on MRI (p = 0.0016 Fisher's exact test test). CONCLUSION: EH(+) or NR in the cVEMP tuning property test correspond well to EH positivity in the MRI findings. The cVEMP tuning property test is useful for screening and following up EH.
PURPOSE: To examine the concordance between cervical vestibular-evoked myogenic potential (cVEMP) tuning property test results and MRI findings of endolymphatic hydrops (EH). METHODS: Fourteen subjects (age 24-76 years) that had been diagnosed with unilateral definite Meniere's disease (MD) (N = 8) or unilateral probable MD (N = 6) were enrolled. All of the subjects underwent cVEMP tests (using 500 Hz and 1000 Hz tone bursts), pure-tone audiometry, and gadolinium-enhanced 3 T-MRI. To examine tuning properties of cVEMP, the 500-1000 Hz amplitude ratio was calculated as the SLOPE. The results of the cVEMP tuning property test results were compared with EH-related MRI findings. RESULTS: EH positivity in both the cochlea and vestibule on MRI was observed in 7 of the 8 affected ears of definite MD and 3 of the 6 affected ears of probable MD, although it was only in one of the 14 unaffected ears. EH(+) or no response (NR) in cVEMP tuning property test was significantly associated with EH positivity on MRI, while EH(-) in the cVEMP tuning property test was significantly associated with EH-negativity on MRI (p = 0.0016 Fisher's exact test test). CONCLUSION: EH(+) or NR in the cVEMP tuning property test correspond well to EH positivity in the MRI findings. The cVEMP tuning property test is useful for screening and following up EH.
Authors: Tsutomu Nakashima; Ilmari Pyykkö; Megan A Arroll; Margaretha L Casselbrant; Carol A Foster; Nauman F Manzoor; Cliff A Megerian; Shinji Naganawa; Yi-Ho Young Journal: Nat Rev Dis Primers Date: 2016-05-12 Impact factor: 52.329
Authors: Woo Seok Kang; Sang Hun Lee; Chan Joo Yang; Joong Ho Ahn; Jong Woo Chung; Hong Ju Park Journal: Front Neurol Date: 2016-09-30 Impact factor: 4.003