Tanis R Fenton1,2, Roseann Nasser3, Dianne Creighton4, Selphee Tang5, Reg Sauve4,6, Denise Bilan3, Carol J Fenton6, Misha Eliasziw7. 1. Community Health Sciences, O'Brien Institute of Public Health, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. tfenton@ucalgary.ca. 2. Nutrition Services, Alberta Health Services, Calgary, AB, Canada. tfenton@ucalgary.ca. 3. Saskatchewan Heath Authority, Nutrition and Food Services, Pasqua Hospital, Regina, SK, Canada. 4. Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. 5. Neonatal Follow-up Clinic, Alberta Health Services, Calgary, AB, Canada. 6. Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. 7. Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
Abstract
OBJECTIVE: To assess diagnostic accuracy of 36-week anthropometric weight, length, and head circumference <10th and <3rd percentiles to predict preterm infant cognitive impairment. STUDY DESIGN: Cohort study of 898 preterm <30-week very-low-birth weight (<1500 g) infants. Anthropometric measures' accuracy to predict cognitive impairment (Bayley-III Cognitive Composite score) <80, 21-months corrected age (CA) and Wechsler Preschool and Primary Scale of Intelligence Quotient (intellectual outcomes) <70, 36-months CA, were determined using receiver operating characteristic (ROC) curves. RESULT: Thirty-six-week weight, length or head circumference <10th or <3rd percentile did not predict cognitive impairment; areas under ROC curves were <0.6. Sensitivities and specificities for 10th and 3rd percentile cut points were all poor, with most not exceeding 70%, whether the Fenton 2013 or INTERGROWTH 2015 growth charts were used. Brain injury and low maternal education were better predictors of cognitive impairment. CONCLUSION: Preterm infant 36-week anthropometric measurements are not accurate predictors of cognitive impairment.
OBJECTIVE: To assess diagnostic accuracy of 36-week anthropometric weight, length, and head circumference <10th and <3rd percentiles to predict preterm infant cognitive impairment. STUDY DESIGN: Cohort study of 898 preterm <30-week very-low-birth weight (<1500 g) infants. Anthropometric measures' accuracy to predict cognitive impairment (Bayley-III Cognitive Composite score) <80, 21-months corrected age (CA) and Wechsler Preschool and Primary Scale of Intelligence Quotient (intellectual outcomes) <70, 36-months CA, were determined using receiver operating characteristic (ROC) curves. RESULT: Thirty-six-week weight, length or head circumference <10th or <3rd percentile did not predict cognitive impairment; areas under ROC curves were <0.6. Sensitivities and specificities for 10th and 3rd percentile cut points were all poor, with most not exceeding 70%, whether the Fenton 2013 or INTERGROWTH 2015 growth charts were used. Brain injury and low maternal education were better predictors of cognitive impairment. CONCLUSION: Preterm infant 36-week anthropometric measurements are not accurate predictors of cognitive impairment.
Authors: Betina Soldateli; Rita C Silveira; Renato Soibelmann Procianoy; Mandy Belfort; Arthur Caye; Douglas Leffa; Adelar Pedro Franz; Fernando C Barros; Iná S Santos; Alicia Matijasevich; Aluisio J D Barros; Luciana Tovo-Rodrigues; Ana M B Menezes; Helen Gonçalves; Fernando C Wehrmeister; Luis Augusto Paim Rohde Journal: Eur Child Adolesc Psychiatry Date: 2022-03-11 Impact factor: 4.785