| Literature DB >> 33036721 |
Lukasz Zareba1, Alex Fitas1, Marta Wolska1, Eva Junger1, Ceren Eyileten1, Zofia Wicik2, Salvatore De Rosa3, Jolanta M Siller-Matula4, Marek Postula5.
Abstract
Noncoding RNAs (ncRNAs), including long noncoding RNAs and microRNAs, play an important role in coronary artery disease onset and progression. The ability of ncRNAs to simultaneously regulate many target genes allows them to modulate various key processes involved in atherosclerosis, including lipid metabolism, smooth muscle cell proliferation, autophagy, and foam cell formation. This review focuses on the therapeutic potential of the most important ncRNAs in coronary artery disease. Moreover, various other promising microRNAs and long noncoding RNAs that attract substantial scientific interest as potential therapeutic targets in coronary artery disease and merit further investigation are presented.Entities:
Keywords: Atherosclerosis; Long noncoding RNA; lncRNAs; miR-155; miR-33; miR-92a; miRNAs; microRNA
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Year: 2020 PMID： 33036721 DOI： 10.1016/j.ccl.2020.07.005
Source DB: PubMed Journal: Cardiol Clin ISSN： 0733-8651 Impact factor: 2.213