Koca Arzu Or1, Murat Dağdeviren1, Tolga Akkan1, İhsan Ateş2, Salim Neşelioğlu3, Özcan Erel3, Mustafa Altay1. 1. University of Health Sciences, Keçiören Health Administration and Research Centre, Department of Endocrinology and Metabolism, Ankara, Turkey. 2. University of Health Sciences, Numune Health Administration and Research Centre, Department of Internal Medicine, Ankara, Turkey. 3. University of Ankara Yıldırım Beyazıt, Department of Medical Biochemistry, Ankara, Turkey.
Abstract
BACKGROUND: In this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels. METHODS: 55 patients with iatrogenic hypoparathyroidism follow-ups and 40 healthy volunteers were included in the study. The blood dynamic thiol/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples. RESULTS: In our study, it was found that the disulfide, disulfide/native thiol, disulfide/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25-hydroxy vitamin D (25-OH vitamin D) and disulfide, disulfide/native thiol and disulfide/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated. CONCLUSIONS: Consequently, a change in favour of disulfide was found in the dynamic thiol-disulfide homeostasis in the hypoparathyroidism group in our study. 2020 Koca Arzu Or, Murat Dağdeviren, Tolga Akkan, İhsan Ateş, Salim Neşelioğlu, Özcan Erel, Mustafa Altay, published by CEON/CEES.
BACKGROUND: In this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels. METHODS: 55 patients with iatrogenic hypoparathyroidism follow-ups and 40 healthy volunteers were included in the study. The blood dynamic thiol/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples. RESULTS: In our study, it was found that the disulfide, disulfide/native thiol, disulfide/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25-hydroxy vitamin D (25-OH vitamin D) and disulfide, disulfide/native thiol and disulfide/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated. CONCLUSIONS: Consequently, a change in favour of disulfide was found in the dynamic thiol-disulfide homeostasis in the hypoparathyroidism group in our study. 2020 Koca Arzu Or, Murat Dağdeviren, Tolga Akkan, İhsan Ateş, Salim Neşelioğlu, Özcan Erel, Mustafa Altay, published by CEON/CEES.
Entities:
Keywords:
disulfide; hypoparathyroidism; paraoxonase; thiol; total antioxidant status; total oxidant status
Authors: Andreas Tomaschitz; Eberhard Ritz; Burkert Pieske; Jutta Rus-Machan; Katharina Kienreich; Nicolas Verheyen; Martin Gaksch; Martin Grübler; Astrid Fahrleitner-Pammer; Peter Mrak; Hermann Toplak; Elisabeth Kraigher-Krainer; Winfried März; Stefan Pilz Journal: Metabolism Date: 2013-10-02 Impact factor: 8.694