BACKGROUND: The purpose of the present study was to assess saliva reliability in diagnosis and monitoring type 2 diabetes instead of blood. METHODS: Blood and unstimulated whole saliva were collected from 300 type 2 diabetic subjects and 300 healthy controls in fasting. Then, the salivary flow rate was calculated. All parameters including glucose, urea, amylase, total protein, albumin, C-reactive protein (CRP), immunoglobulin A (IgA), potassium, calcium and chloride were assessed in the supernatant, using an autoanalyzer. Oral exam was conducted by a single examiner on full mouth excluding third molars. Statistical analysis was performed by the SPSS 20.0 version. RESULTS: Saliva screening showed that glucose, urea, amylase, total protein, potassium, calcium and chloride were significantly higher in patients compared to controls (p < 0.05). Whereas, the IgA level and salivary flow rate were significantly reduced in patients (p < 0.05). No significant difference was found in albumin and CRP levels (p > 0.05). There was a significant positive correlation between salivary and plasma glucose levels (r = 0.887, and r = 0.900, p < 0.001), as well as, salivary and blood urea (r = 0.586, and r = 0.688, p < 0.001) in patients and controls, respectively. CONCLUSIONS: From this study, saliva could be suggested as a useful diagnostic tool for type 2 diabetes. 2020 Marwa Mrag, Asma Kassab, Asma Omezzine, Chebil Raoua Belkacem, Fredj Ismail Fatma Ben, Nabiha Douki, Kechrid Chedia Laouani, Ali Bouslema, Amor Faten Ben, published by CEON/CEES.
BACKGROUND: The purpose of the present study was to assess saliva reliability in diagnosis and monitoring type 2 diabetes instead of blood. METHODS: Blood and unstimulated whole saliva were collected from 300 type 2 diabetic subjects and 300 healthy controls in fasting. Then, the salivary flow rate was calculated. All parameters including glucose, urea, amylase, total protein, albumin, C-reactive protein (CRP), immunoglobulin A (IgA), potassium, calcium and chloride were assessed in the supernatant, using an autoanalyzer. Oral exam was conducted by a single examiner on full mouth excluding third molars. Statistical analysis was performed by the SPSS 20.0 version. RESULTS: Saliva screening showed that glucose, urea, amylase, total protein, potassium, calcium and chloride were significantly higher in patients compared to controls (p < 0.05). Whereas, the IgA level and salivary flow rate were significantly reduced in patients (p < 0.05). No significant difference was found in albumin and CRP levels (p > 0.05). There was a significant positive correlation between salivary and plasma glucose levels (r = 0.887, and r = 0.900, p < 0.001), as well as, salivary and blood urea (r = 0.586, and r = 0.688, p < 0.001) in patients and controls, respectively. CONCLUSIONS: From this study, saliva could be suggested as a useful diagnostic tool for type 2 diabetes. 2020 Marwa Mrag, Asma Kassab, Asma Omezzine, Chebil Raoua Belkacem, Fredj Ismail Fatma Ben, Nabiha Douki, Kechrid Chedia Laouani, Ali Bouslema, Amor Faten Ben, published by CEON/CEES.
Authors: Carmen Carda; Nezly Mosquera-Lloreda; Lucas Salom; Maria Elsa Gomez de Ferraris; Amando Peydró Journal: Med Oral Patol Oral Cir Bucal Date: 2006-07-01
Authors: Monica Virginia Viegas Lima-Aragão; João de Jesus de Oliveira-Junior; Márcia Cristina Gonçalves Maciel; Lucilene Amorim Silva; Flávia Raquel Fernandes do Nascimento; Rosane Nassar Meireles Guerra Journal: BMC Res Notes Date: 2016-02-16
Authors: Habiba Ben Romdhane; Samir Ben Ali; Wafa Aissi; Pierre Traissac; Hajer Aounallah-Skhiri; Souha Bougatef; Bernard Maire; Francis Delpeuch; Noureddine Achour Journal: BMC Public Health Date: 2014-01-28 Impact factor: 3.295