Jingkai Wei1, Ruixue Hou2, Liyang Xie3, Eeshwar K Chandrasekar4, Haidong Lu5, Tiansheng Wang5, Changwei Li6, Hanzhang Xu7. 1. Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, United States. Electronic address: jwei25@gwu.edu. 2. Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States. 3. Medical Research Center, University of Pittsburgh, Pittsburgh, PA, United States. 4. School of Medicine, Emory University, Atlanta, GA, United States. 5. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, United States. 6. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States. 7. Department of Family Medicine and Community Health, School of Medicine, Duke University, Durham, NC, United States; School of Nursing, Duke University, Durham, NC, United States.
Abstract
OBJECTIVES: We aimed to estimate the association of sleep, sedentary activity and physical activity with cognitive function among older adults, with consideration of the competing nature between variables of activity status. DESIGN: Cross-sectional study. METHODS: A total of 3086 older adults (60 years or older) in the 2011-2014 National Health and Nutrition Examination Survey were included. The Global Physical Activity Questionnaire was used to measure self-reported time for sedentary activity, walking/bicycling and moderate-to-vigorous physical activity (MVPA). Cognitive function was examined using the CERAD Word Learning subtest (memory), Digit Symbol Substitution Test (executive function/processing speed), and Animal Fluency Test (language). Sleep duration was obtained via interview. Isotemporal substitution models using multivariable linear regression were applied to examine the associations of replacing sleep, sedentary activity, walking/bicycling, MVPA with each other and cognitive function, stratified by sleep duration per night (≤7h, >7h). RESULTS: Among participants with sleep duration ≤7h/night, replacing 30min/day of sedentary activity with 30min/day of MVPA or 30min/day was associated with better cognition. Among participants with sleep duration >7h/night, replacing 30min/day of sleep with 30min/day of sedentary activity, walking/bicycling, or MVPA was associated with better cognition. CONCLUSIONS: Replacing sedentary activities with MVPA was associated with favorable cognitive function among older adults sleeping no longer than 7h/night, and replacing excessive sleep with sedentary or physical activities was associated with favorable cognition. Future research is expected to examine the associations of replacing different activity status on long-term cognitive outcomes in longitudinal studies.
OBJECTIVES: We aimed to estimate the association of sleep, sedentary activity and physical activity with cognitive function among older adults, with consideration of the competing nature between variables of activity status. DESIGN: Cross-sectional study. METHODS: A total of 3086 older adults (60 years or older) in the 2011-2014 National Health and Nutrition Examination Survey were included. The Global Physical Activity Questionnaire was used to measure self-reported time for sedentary activity, walking/bicycling and moderate-to-vigorous physical activity (MVPA). Cognitive function was examined using the CERAD Word Learning subtest (memory), Digit Symbol Substitution Test (executive function/processing speed), and Animal Fluency Test (language). Sleep duration was obtained via interview. Isotemporal substitution models using multivariable linear regression were applied to examine the associations of replacing sleep, sedentary activity, walking/bicycling, MVPA with each other and cognitive function, stratified by sleep duration per night (≤7h, >7h). RESULTS: Among participants with sleep duration ≤7h/night, replacing 30min/day of sedentary activity with 30min/day of MVPA or 30min/day was associated with better cognition. Among participants with sleep duration >7h/night, replacing 30min/day of sleep with 30min/day of sedentary activity, walking/bicycling, or MVPA was associated with better cognition. CONCLUSIONS: Replacing sedentary activities with MVPA was associated with favorable cognitive function among older adults sleeping no longer than 7h/night, and replacing excessive sleep with sedentary or physical activities was associated with favorable cognition. Future research is expected to examine the associations of replacing different activity status on long-term cognitive outcomes in longitudinal studies.
Authors: Erin E Dooley; Priya Palta; Dana L Wolff-Hughes; Pablo Martinez-Amezcua; John Staudenmayer; Richard P Troiano; Kelley Pettee Gabriel Journal: Med Sci Sports Exerc Date: 2022-04-06