José Meneses Calderón1, Ma Del Rocío Figueroa Flores2, Leopoldo Paniagua Coria3, Jesús Carlos Briones Garduño4, Jazmín Meneses Figueroa5, María José Vargas Contretas6, Lilia De la Cruz Ávila7, Salvador Díaz Meza8, Reynaldo Ramírez Chacón9, Srivatsan Padmanabhan10, Hugo Mendieta Zerón11. 1. "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico. uci20042000@yahoo.com.mx. 2. Private Practice, Toluca, Mexico. inv.maternoperinatal@gmail.com. 3. "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico. lpaniaguac937@profesor.uaemex.mx. 4. "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico. drcarlosbriones@yahoo.com.mx. 5. Faculty of Medicine, Autonomous University of the State of Mexico (UAEMéx), Toluca, Mexico. jmenesesf428@alumno.uaemex.mx. 6. Faculty of Medicine, Autonomous University of the State of Mexico (UAEMéx), Toluca, Mexico. mvargasc909@alumno.uaemex.mx. 7. "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico. cual14@hotmail.com. 8. "Dr. Nicolás San Juan" General Hospital, Toluca, Mexico. internista62@gmail.com. 9. Instituto de Seguridad Social al Servicio de los Trabajadores del Estado (ISSSTE), Tabasco, Mexico. Rey1972@prodigy.net. 10. St. Joseph Medical Center, Tacoma, WA, United States. psrivats@outlook.com. 11. "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Toluca, Mexico. drmendietaz@yahoo.com.
Abstract
INTRODUCTION: Nitazoxanide has shown efficacy in vitro against coronavirus infections (MERS, SARS, SARS-CoV-2). The aim of this report is to describe the results of treating COVID-19 positive patients with nitazoxanide in three clinical settings: pregnancy/puerperium, hospitalized patients in an Internal Medicine Service and in an ambulatory setting. METHODOLOGY: This was a prospective follow-up and report of COVID-19 cases in three different situations, pregnant women, hospitalized patients receiving medical attention in an Internal Medicine Service and ambulatory patients residing in Toluca City, and Mexico City. RESULTS: The experience with a first group of 20 women, pregnant (17) or in immediate puerperium (3) was successful in 18 cases with two unfortunate deaths. The five cases treated in an Internal Medicine service showed a positive outcome with two patients weaned from mechanical ventilation. Of the remaining 16 patients treated in an ambulatory setting, all got cured. Nitazoxanide seems to be useful against SARS-CoV-2, not only in an early intervention but also in critical condition as well as in pregnancy without undesired effects for the babies. As an adjunctive therapy budesonide was used that seems to contribute to the clinical improvement. CONCLUSIONS: Nitazoxanide could be useful against COVID-19 as a safe and available regimen to be tested in a massive way immediately. Copyright (c) 2020 Jose Meneses Calderon, Ma. del Rocio Figueroa Flores, Leopoldo Paniagua Coria, Jesus Carlos Briones Garduno, Jazmin Meneses Figueroa, Maria Jose Vargas Contretas, Lilia de la Cruz Avila, Salvador Diaz Meza, Reynaldo Ramirez Chacon, Srivatsan Padmanabhan, Hugo Mendieta Zeron.
INTRODUCTION:Nitazoxanide has shown efficacy in vitro against coronavirus infections (MERS, SARS, SARS-CoV-2). The aim of this report is to describe the results of treating COVID-19 positive patients with nitazoxanide in three clinical settings: pregnancy/puerperium, hospitalized patients in an Internal Medicine Service and in an ambulatory setting. METHODOLOGY: This was a prospective follow-up and report of COVID-19 cases in three different situations, pregnant women, hospitalized patients receiving medical attention in an Internal Medicine Service and ambulatory patients residing in Toluca City, and Mexico City. RESULTS: The experience with a first group of 20 women, pregnant (17) or in immediate puerperium (3) was successful in 18 cases with two unfortunate deaths. The five cases treated in an Internal Medicine service showed a positive outcome with two patients weaned from mechanical ventilation. Of the remaining 16 patients treated in an ambulatory setting, all got cured. Nitazoxanide seems to be useful against SARS-CoV-2, not only in an early intervention but also in critical condition as well as in pregnancy without undesired effects for the babies. As an adjunctive therapy budesonide was used that seems to contribute to the clinical improvement. CONCLUSIONS:Nitazoxanide could be useful against COVID-19 as a safe and available regimen to be tested in a massive way immediately. Copyright (c) 2020 Jose Meneses Calderon, Ma. del Rocio Figueroa Flores, Leopoldo Paniagua Coria, Jesus Carlos Briones Garduno, Jazmin Meneses Figueroa, Maria Jose Vargas Contretas, Lilia de la Cruz Avila, Salvador Diaz Meza, Reynaldo Ramirez Chacon, Srivatsan Padmanabhan, Hugo Mendieta Zeron.
Authors: Krista Yazareth Enríquez López; José Meneses Calderón; Lilia de la Cruz Ávila; Miguel Ángel López Esquivel; Jazmín Meneses Figueroa; María José Vargas Contreras; José Anaya Herrera; Ofelia Roxana Sotelo Martínez; José Antonio Mendoza López; Hugo Mendieta Zerón Journal: Cureus Date: 2021-05-13