Patrycja K Gazy1,2, Sylwia Marciniak3,4, Helena Slawska3,4, Anita Olejek4, Bogdan Mazur5. 1. Chair and Department of Microbiology and Immunology in Zabrze, Medical University of Silesia. gazypatrycja@gmail.com. 2. Specialist Hospital No 2 in Bytom, Neonatal Unit No 5, Bytom, Poland. gazypatrycja@gmail.com. 3. Specialist Hospital No 2 in Bytom, Neonatal Unit No 5, Bytom, Poland. 4. Department of Gynecology, Obstetrics and Gynecologic Oncology in Bytom, School of Medicine With the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Bytom, Poland. 5. Chair and Department of Microbiology and Immunology in Zabrze, Medical University of Silesia.
Abstract
OBJECTIVES: The aim of the study was to compare Insulin-like Growth Factor-1 (IGF-1)concentration in pregnancies complicated by pregnancy-induced hypertension and/or intrauterine hypotrophy, and its correlation with maternal pressure and umbilical artery pulsatility and resistance indices. MATERIAL AND METHODS: 65 pairs pregnant-newborn were included to four groups: I - control, II - PIH, III - Hypotrophy, IV - PIH and Hypotrophy. In the study we analyzed cord blood IGF-1 concentration, newborns antropometry, umbilical artery pulsatility and resistance indices and maternal pressure before delivery. RESULTS: The concentration of IGF-1 was the lowest in IV group of hypotrophic newborns from pregnancies complicated by pregnancy-induced hypertension. In this group of patients there was strong negative correlation between IGF-1 concentration and maternal systolic and diastolic pressure. CONCLUSIONS: There is a strong negative correlation between IGF-1 concentration and maternal systolic pressure in group of hypotrophic newborns from pregnancies complicated by pregnancy-induced hypertension.
OBJECTIVES: The aim of the study was to compare Insulin-like Growth Factor-1 (IGF-1)concentration in pregnancies complicated by pregnancy-induced hypertension and/or intrauterine hypotrophy, and its correlation with maternal pressure and umbilical artery pulsatility and resistance indices. MATERIAL AND METHODS: 65 pairs pregnant-newborn were included to four groups: I - control, II - PIH, III - Hypotrophy, IV - PIH and Hypotrophy. In the study we analyzed cord blood IGF-1 concentration, newborns antropometry, umbilical artery pulsatility and resistance indices and maternal pressure before delivery. RESULTS: The concentration of IGF-1 was the lowest in IV group of hypotrophic newborns from pregnancies complicated by pregnancy-induced hypertension. In this group of patients there was strong negative correlation between IGF-1 concentration and maternal systolic and diastolic pressure. CONCLUSIONS: There is a strong negative correlation between IGF-1 concentration and maternal systolic pressure in group of hypotrophic newborns from pregnancies complicated by pregnancy-induced hypertension.