Hai Nguyen1, Yu-Tzu Wu1, Alexandru Dregan2, Silia Vitoratou3, Kia-Chong Chua4, A Matthew Prina1. 1. Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. 2. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. 3. Psychometrics and Measurement Lab, Biostatistics and Health Informatics Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. 4. Center for Implementation Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Abstract
AIM: This study aimed to investigate the relationships between multimorbidity, healthy aging and mortality. METHODS: Using data from 9171 individuals aged ≥50 years at wave 2 and mortality data at wave 5 of the English Longitudinal Study of Aging, a multiple linear regression model and a Cox proportional hazards model were used to investigate how multimorbidity patterns (identified as cardiorespiratory/arthritis/cataracts, metabolic and relatively healthy) were associated with a composite index of healthy aging (derived from 41 intrinsic capacity and functional ability items) and with mortality. RESULTS: A total of 60% of the sample with multimorbidity had a moderate or high level of healthy aging. Both the cardiorespiratory/arthritis/cataracts group (n = 1826) and the metabolic group (n = 844) were negatively associated with healthy aging. The expected healthy aging index score decreased by 5.81 points (95% CI -6.69, -4.92) for the first group, and by 2.39 points (95% CI -3.54, -1.24) for the latter group. Only the cardiorespiratory/arthritis/cataracts group was positively associated with mortality. The risk of death for this group was 1.27-fold (95% CI: 1.14, 1.43) than the relatively healthy group. The relationship between multimorbidity patterns and mortality did not differ when considering levels of healthy aging. CONCLUSIONS: Although it is not impossible for people with multimorbidity to age healthily, those with the most complex combination of diseases are at higher risk of death and have lower levels of healthy aging. Geriatr Gerontol Int 2020; 20: 1126-1132.
AIM: This study aimed to investigate the relationships between multimorbidity, healthy aging and mortality. METHODS: Using data from 9171 individuals aged ≥50 years at wave 2 and mortality data at wave 5 of the English Longitudinal Study of Aging, a multiple linear regression model and a Cox proportional hazards model were used to investigate how multimorbidity patterns (identified as cardiorespiratory/arthritis/cataracts, metabolic and relatively healthy) were associated with a composite index of healthy aging (derived from 41 intrinsic capacity and functional ability items) and with mortality. RESULTS: A total of 60% of the sample with multimorbidity had a moderate or high level of healthy aging. Both the cardiorespiratory/arthritis/cataracts group (n = 1826) and the metabolic group (n = 844) were negatively associated with healthy aging. The expected healthy aging index score decreased by 5.81 points (95% CI -6.69, -4.92) for the first group, and by 2.39 points (95% CI -3.54, -1.24) for the latter group. Only the cardiorespiratory/arthritis/cataracts group was positively associated with mortality. The risk of death for this group was 1.27-fold (95% CI: 1.14, 1.43) than the relatively healthy group. The relationship between multimorbidity patterns and mortality did not differ when considering levels of healthy aging. CONCLUSIONS: Although it is not impossible for people with multimorbidity to age healthily, those with the most complex combination of diseases are at higher risk of death and have lower levels of healthy aging. Geriatr Gerontol Int 2020; 20: 1126-1132.
Authors: Syed Mustafa Ali; David A Selby; Kazi Khalid; Katherine Dempsey; Elaine Mackey; Nicola Small; Sabine N van der Veer; Brian Mcmillan; Peter Bower; Benjamin Brown; John McBeth; William G Dixon Journal: J Multimorb Comorb Date: 2021-11-30
Authors: Shimin Chen; Shengshu Wang; Wangping Jia; Ke Han; Yang Song; Shaohua Liu; Xuehang Li; Miao Liu; Yao He Journal: Front Med (Lausanne) Date: 2022-01-20
Authors: Maria Lisa Odland; Samiha Ismail; Sadaf G Sepanlou; Hossein Poustchi; Alireza Sadjadi; Akram Pourshams; Tom Marshall; Miles D Witham; Reza Malekzadeh; Justine I Davies Journal: BMJ Glob Health Date: 2022-05
Authors: Hsin-En Ho; Chih-Jung Yeh; James Cheng-Chung Wei; Wei-Min Chu; Meng-Chih Lee Journal: Int J Environ Res Public Health Date: 2022-03-11 Impact factor: 3.390