Literature DB >> 33030

N-Didemethyl-n-propionyl-6,9;9, 12-erythromycin A-spiroketal, a new metabolite of erythromycin ethyl succinate in man.

J Majer, R S Stanaszek, S L Mueller, G Marti.   

Abstract

A novel, neutral metabolite of erythromycin was isolated from the urine of a patient treated with erythromycin ethyl succinate. After separation and purification on Sephadex LH-20 column chromatography, the structure of the metabolite was deduced from spectral data to be the propionamide of the didemethylated 6,9;9, 12-spiroketal of erythromycin A.

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Year:  1978        PMID: 33030

Source DB:  PubMed          Journal:  Drug Metab Dispos        ISSN: 0090-9556            Impact factor:   3.922


  3 in total

1.  Autobacteriographic studies of clarithromycin and erythromycin in mice.

Authors:  Y Kohno; K Ohta; T Suwa; T Suga
Journal:  Antimicrob Agents Chemother       Date:  1990-04       Impact factor: 5.191

2.  In vitro induction of resistance to erythromycin by its metabolite.

Authors:  J Majer
Journal:  Antimicrob Agents Chemother       Date:  1981-04       Impact factor: 5.191

3.  Comparative pharmacokinetics of clarithromycin (TE-031), a new macrolide antibiotic, and erythromycin in rats.

Authors:  Y Kohno; H Yoshida; T Suwa; T Suga
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

  3 in total

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