Harry Jin1, Katie Biello1,2,3, Robert Garofalo4,5, Mark Lurie1, Patrick S Sullivan6, Rob Stephenson7, Matthew J Mimiaga1,2,3,8. 1. Department of Epidemiology, Brown University School of Public Health, Providence, RI. 2. Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. 3. The Fenway Institute, Fenway Health, Boston, MA. 4. Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. 5. Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL. 6. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA. 7. Department of Systems, Population and Leadership and The Center for Sexuality and Health Disparities, School of Nursing, University of Michigan, Ann Arbor, MI; and. 8. Department of Psychiatry and Human Behavior, Brown University Alpert Medical School, Providence, RI.
Abstract
BACKGROUND: Men who have sex with men are disproportionately burdened by HIV/AIDS, and the advent of pre-exposure prophylaxis (PrEP) has provided an effective strategy to reduce the risk of HIV transmission. Research has shown that improving one partner's health-promoting behaviors increases the likelihood that their partner adopts healthier behaviors. We examined the longitudinal relationship between favorable HIV treatment outcomes with current PrEP use among HIV serodiscordant male partners. SETTING: Data are from Project Stronger Together, a randomized controlled trial that recruited serodiscordant male couples from Atlanta, GA; Boston, MA; and Chicago, IL. METHODS: Serodiscordant couples completed assessments at baseline, 6, 12, 18, and 24 months. We analyzed longitudinal data from 120 HIV serodiscordant male partners to assess the relationship between the HIV-negative partner's current PrEP use and their HIV-positive partner's current ART use, ART adherence, and viral load using generalized estimating equation models. RESULTS: Fewer than half of the HIV-negative partners were on PrEP at baseline and nearly two-thirds of their HIV-positive partners were virally suppressed. HIV-negative male partners who had partners with an undetectable viral load had greater odds of being a current PrEP user than HIV-negative partners with partners with a detectable viral load. CONCLUSION: Our study highlights the need to develop dyad-level interventions to improve HIV medication use/adherence by HIV serodiscordant male couples. Our findings also suggest that dyad-level interventions may be able to leverage our understanding of how partners can influence each other's health-promoting behaviors to develop programs that improve health outcomes for both partners.
BACKGROUND: Men who have sex with men are disproportionately burdened by HIV/AIDS, and the advent of pre-exposure prophylaxis (PrEP) has provided an effective strategy to reduce the risk of HIV transmission. Research has shown that improving one partner's health-promoting behaviors increases the likelihood that their partner adopts healthier behaviors. We examined the longitudinal relationship between favorable HIV treatment outcomes with current PrEP use among HIV serodiscordant male partners. SETTING: Data are from Project Stronger Together, a randomized controlled trial that recruited serodiscordant male couples from Atlanta, GA; Boston, MA; and Chicago, IL. METHODS: Serodiscordant couples completed assessments at baseline, 6, 12, 18, and 24 months. We analyzed longitudinal data from 120 HIV serodiscordant male partners to assess the relationship between the HIV-negative partner's current PrEP use and their HIV-positive partner's current ART use, ART adherence, and viral load using generalized estimating equation models. RESULTS: Fewer than half of the HIV-negative partners were on PrEP at baseline and nearly two-thirds of their HIV-positive partners were virally suppressed. HIV-negative male partners who had partners with an undetectable viral load had greater odds of being a current PrEP user than HIV-negative partners with partners with a detectable viral load. CONCLUSION: Our study highlights the need to develop dyad-level interventions to improve HIV medication use/adherence by HIV serodiscordant male couples. Our findings also suggest that dyad-level interventions may be able to leverage our understanding of how partners can influence each other's health-promoting behaviors to develop programs that improve health outcomes for both partners.
Authors: Robert M Grant; Javier R Lama; Peter L Anderson; Vanessa McMahan; Albert Y Liu; Lorena Vargas; Pedro Goicochea; Martín Casapía; Juan Vicente Guanira-Carranza; Maria E Ramirez-Cardich; Orlando Montoya-Herrera; Telmo Fernández; Valdilea G Veloso; Susan P Buchbinder; Suwat Chariyalertsak; Mauro Schechter; Linda-Gail Bekker; Kenneth H Mayer; Esper Georges Kallás; K Rivet Amico; Kathleen Mulligan; Lane R Bushman; Robert J Hance; Carmela Ganoza; Patricia Defechereux; Brian Postle; Furong Wang; J Jeff McConnell; Jia-Hua Zheng; Jeanny Lee; James F Rooney; Howard S Jaffe; Ana I Martinez; David N Burns; David V Glidden Journal: N Engl J Med Date: 2010-11-23 Impact factor: 91.245
Authors: Kenneth H Mayer; Steven A Safren; Steven A Elsesser; Christina Psaros; Jake P Tinsley; Mark Marzinke; William Clarke; Craig Hendrix; S Wade Taylor; Jessica Haberer; Matthew J Mimiaga Journal: AIDS Behav Date: 2017-05
Authors: Michael E Newcomb; Kevin Moran; Brian A Feinstein; Emily Forscher; Brian Mustanski Journal: J Acquir Immune Defic Syndr Date: 2018-04-01 Impact factor: 3.731
Authors: Bradley H Wagenaar; Lauren Christiansen-Lindquist; Christine Khosropour; Laura F Salazar; Nanette Benbow; Nik Prachand; R Craig Sineath; Rob Stephenson; Patrick S Sullivan Journal: PLoS One Date: 2012-08-14 Impact factor: 3.240
Authors: Rob Stephenson; Nicolas A Suarez; Robert Garofalo; Marco A Hidalgo; Samuel Hoehnle; Jennie Thai; Matthew J Mimiaga; Emily Brown; Anna Bratcher; Taylor Wimbly; Patrick Sullivan Journal: JMIR Res Protoc Date: 2017-08-31