Helena Crom1, Hans-Joachim Trappe2. 1. Medizinische Klinik II - Kardiologie und Angiologie, Marien Hospital Herne, Ruhr-Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland. 2. Medizinische Klinik II - Kardiologie und Angiologie, Marien Hospital Herne, Ruhr-Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland. hans-joachim.trappe@elisabethgruppe.de.
Abstract
INTRODUCTION: Stress is a risk factor for the development of cardiovascular diseases. New analytical methods enable the determination of cortisol concentrations in hair (HCC) as a retrospective long-term parameter for chronic stress. So far, it is still uncertain whether stress objectively measured by an increase in HCC might be a predictive factor associated with the development of an acute myocardial infarction. METHODS: Included in this study were 40 patients with an acute ST-segment elevation myocardial infarction (STEMI), confirmed by electrocardiography (ECG). The control group consisted of 80 patients without coronary artery disease (CAD). RESULTS: Patients with STEMI did not show significantly higher HCCs (p = 0.846) compared to the control group and there was no correlation with the extent of myocardial infarction (p = 0.701, r = 0.038). Correlations were found between HCC, diabetes mellitus (p = 0.046, odds ratio, OR = 6.346), low high-density lipoprotein (HDL) cholesterol concentration (p = 0.107) and glycated hemoglobin A (HbA1c) concentration (p = 0.083, r = 0.236). Furthermore, there was an association between an increased HCC and chronic heart failure (p = 0.110) and an association to the red blood cell distribution width (RDW) concentration (p = 0.005, r = 0.293). CONCLUSION: The results of this study showed that patients with acute ST-segment elevation myocardial infarction did not have significantly higher levels of hair cortisol compared to the reference group; however, long-term metabolic changes as well as advanced chronic heart failure appear to be long-acting stress factors for the organism and increase cortisol levels in hair.
INTRODUCTION: Stress is a risk factor for the development of cardiovascular diseases. New analytical methods enable the determination of cortisol concentrations in hair (HCC) as a retrospective long-term parameter for chronic stress. So far, it is still uncertain whether stress objectively measured by an increase in HCC might be a predictive factor associated with the development of an acute myocardial infarction. METHODS: Included in this study were 40 patients with an acute ST-segment elevation myocardial infarction (STEMI), confirmed by electrocardiography (ECG). The control group consisted of 80 patients without coronary artery disease (CAD). RESULTS: Patients with STEMI did not show significantly higher HCCs (p = 0.846) compared to the control group and there was no correlation with the extent of myocardial infarction (p = 0.701, r = 0.038). Correlations were found between HCC, diabetes mellitus (p = 0.046, odds ratio, OR = 6.346), low high-density lipoprotein (HDL) cholesterol concentration (p = 0.107) and glycated hemoglobin A (HbA1c) concentration (p = 0.083, r = 0.236). Furthermore, there was an association between an increased HCC and chronic heart failure (p = 0.110) and an association to the red blood cell distribution width (RDW) concentration (p = 0.005, r = 0.293). CONCLUSION: The results of this study showed that patients with acute ST-segment elevation myocardial infarction did not have significantly higher levels of hair cortisol compared to the reference group; however, long-term metabolic changes as well as advanced chronic heart failure appear to be long-acting stress factors for the organism and increase cortisol levels in hair.
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