Literature DB >> 33024267

Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma.

Nidhi Pamidimukkala1, Gemma S Puts1, M Kathryn Leonard1,2, Devin Snyder1, Sandrine Dabernat3, Edward C De Fabo4, Frances P Noonan4, Andrzej Slominski5, Glenn Merlino6, David M Kaetzel7,8,9.   

Abstract

NME1 is a metastasis-suppressor gene (MSG), capable of suppressing metastatic activity in cell lines of melanoma, breast carcinoma and other cancer origins without affecting their growth in culture or as primary tumours. Herein, we selectively ablated the tandemly arranged Nme1 and Nme2 genes to assess their individual impacts on metastatic activity in a mouse model (HGF:p16-/-) of ultraviolet radiation (UVR)-induced melanoma. Metastatic activity was strongly enhanced in both genders of Nme1- and Nme2-null mice, with stronger activity in females across all genotypes. The study ascribes MSG activity to Nme2 for the first time in an in vivo model of spontaneous cancer, as well as a novel metastasis-suppressor function to Nme1 in the specific context of UVR-induced melanoma.

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Year:  2020        PMID： 33024267      PMCID： PMC7782836          DOI： 10.1038/s41416-020-01096-w

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  17 in total

1.  Nucleoside diphosphate kinase B knock-out mice have impaired activation of the K+ channel KCa3.1, resulting in defective T cell activation.

Authors:  Lie Di; Shekhar Srivastava; Olga Zhdanova; Yi Sun; Zhai Li; Edward Y Skolnik
Journal:  J Biol Chem       Date:  2010-09-30       Impact factor: 5.157

2.  Increased lung metastasis in transgenic NM23-Null/SV40 mice with hepatocellular carcinoma.

Authors:  Mathieu Boissan; Dominique Wendum; Sandrine Arnaud-Dabernat; Annie Munier; Marcel Debray; Ioan Lascu; Jean-Yves Daniel; Marie-Lise Lacombe
Journal:  J Natl Cancer Inst       Date:  2005-06-01       Impact factor: 13.506

3.  Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis.

Authors:  Juan A Recio; Frances P Noonan; Hisashi Takayama; Miriam R Anver; Paul Duray; Walter L Rush; Gerd Lindner; Edward C De Fabo; Ronald A DePinho; Glenn Merlino
Journal:  Cancer Res       Date:  2002-11-15       Impact factor: 12.701

4.  Metastasis suppressor function of NM23-H1 requires its 3'-5' exonuclease activity.

Authors:  Qingbei Zhang; Joseph R McCorkle; Marian Novak; Mengmeng Yang; David M Kaetzel
Journal:  Int J Cancer       Date:  2011-01-01       Impact factor: 7.396

5.  Neonatal sunburn and melanoma in mice.

Authors:  F P Noonan; J A Recio; H Takayama; P Duray; M R Anver; W L Rush; E C De Fabo; G Merlino
Journal:  Nature       Date:  2001-09-20       Impact factor: 49.962

6.  Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.

Authors:  Linda J Valentijn; Jan Koster; Rogier Versteeg
Journal:  Genomics       Date:  2006-01-25       Impact factor: 5.736

Review 7.  Nm23/nucleoside diphosphate kinase in human cancers.

Authors:  M T Hartsough; P S Steeg
Journal:  J Bioenerg Biomembr       Date:  2000-06       Impact factor: 2.945

Review 8.  Knockout mice as model systems for studying nm23/NDP kinase gene functions. Application to the nm23-M1 gene.

Authors:  S Arnaud-Dabernat; P M Bourbon; A Dierich; M Le Meur; J Y Daniel
Journal:  J Bioenerg Biomembr       Date:  2003-02       Impact factor: 2.945

9.  Mix and match of the tumor metastasis suppressor Nm23 protein isoforms in vitro and in vivo.

Authors:  Clement M Potel; Domenico Fasci; Albert J R Heck
Journal:  FEBS J       Date:  2018-06-19       Impact factor: 5.542

10.  A rare subpopulation of melanoma cells with low expression of metastasis suppressor NME1 is highly metastatic in vivo.

Authors:  Devin Snyder; Ying Wang; David M Kaetzel
Journal:  Sci Rep       Date:  2020-02-06       Impact factor: 4.379
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  4 in total

Review 1.  The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval.

Authors:  Mariana Matias; Jacinta O Pinho; Maria João Penetra; Gonçalo Campos; Catarina Pinto Reis; Maria Manuela Gaspar
Journal:  Cells       Date:  2021-11-09       Impact factor: 6.600

2.  Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients.

Authors:  M Kathryn Leonard; Gemma S Puts; Nidhi Pamidimukkala; Gautam Adhikary; Yili Xu; Eric Kwok; Yuxin Jin; Devin Snyder; Nicolette Matsangos; Marián Novak; Anup Mahurkar; Amol C Shetty; Radomir M Slominski; Edward C De Fabo; Frances P Noonan; Chi-Ping Day; Mohammed Rigi; Andrzej T Slominski; Michelle G Webb; David W Craig; Glenn Merlino; Richard L Eckert; John D Carpten; Zarko Manojlovic; David M Kaetzel
Journal:  Oncogene       Date:  2021-08-25       Impact factor: 9.867

3.  Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance.

Authors:  Martina Radić; Ignacija Vlašić; Maja Jazvinšćak Jembrek; Anđela Horvat; Ana Tadijan; Maja Sabol; Marko Dužević; Maja Herak Bosnar; Neda Slade
Journal:  Int J Mol Sci       Date:  2022-08-31       Impact factor: 6.208

4.  Decidua Parietalis Mesenchymal Stem/Stromal Cells and Their Secretome Diminish the Oncogenic Properties of MDA231 Cells In Vitro.

Authors:  Yasser Basmaeil; Eman Bahattab; Abdullah Al Subayyil; Haya Bin Kulayb; Maha Alrodayyan; Mohammad Abumaree; Tanvir Khatlani
Journal:  Cells       Date:  2021-12-10       Impact factor: 6.600
  4 in total

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