Reger R Mikaeel1,2,3,4, Joanne P Young1,2,3, Jennifer E Hardingham1,2,3, Gonzalo Tapia Rico5, Peter J Hewett6, Erin L Symonds7,8, Suzanne Edwards9, Eric Smith1,6, Yoko Tomita1, Wendy Uylaki1,10, Mehgan Horsnell1, Timothy J Price1,3. 1. Department of Haematology and Oncology, The Queen Elizabeth Hospital , Woodville South, Australia. 2. SAHMRI Colorectal Node, Basil Hetzel Institute , Woodville South, Australia. 3. Faculty of Health and Medical Sciences, University of Adelaide , Adelaide, Australia. 4. Department of Biology, College of Science, University of Duhok , Duhok, Kurdistan. 5. Department of Medical Oncology, Royal Adelaide Hospital , Adelaide, Australia. 6. University of Adelaide Department of Surgery, The Queen Elizabeth Hospital , Woodville South, Australia. 7. Bowel Health Service, Flinders Medical Centre , Bedford Park, Australia. 8. Finders Centre for Innovation in Cancer, Flinders University , Bedford Park, Australia. 9. Adelaide Health Technology Assessment (AHTA), School of Public Health, The University of Adelaide , Adelaide, Australia. 10. Department of Gastroenterology, The Queen Elizabeth Hospital , Woodville South, Australia.
Abstract
OBJECTIVES: The study aimed to examine the incidence and mortality rates of appendiceal neoplasms (ANs) in Australia. METHODS: A retrospective analysis was performed on national data obtained from the Australian Institute of Health and Welfare (AIHW) from 1982 to 2013. Changes to the incidence, and the cancer-specific mortality following the diagnosis of ANs were analyzed over this time period, with stratification performed for histological subtype, gender, and age groups (<50y and ≥50y). RESULTS: Incidence and mortality rates of ANs increased significantly across both genders and age groups. Incidence rates increased by 415%, from 0.40/100 000 population in 1982 to 2.06/100 000 in 2013. Overall mortality rates increased by 130%, from 0.057/100 000 during 1982-1985 to 0.131/100 000 during 2010-2013. Controlling for age group and gender, the incidence rates increased by 20% every four years (Incidence rate ratio (IRR) = 1.20, 95% confidence interval (CI): 1.17, 1.23, global P value<0.0001), and controlling for age, the mortality rates increased by 8% every four years (IRR = 1.08, 95% CI: 1.00, 1.17, global P-value = 0.0401). CONCLUSION: The increasing use of CT scanning, improvements in pathological assessment of the appendix, and the growing aging population may have contributed in part to the apparent rise in the incidence of ANs.
OBJECTIVES: The study aimed to examine the incidence and mortality rates of appendiceal neoplasms (ANs) in Australia. METHODS: A retrospective analysis was performed on national data obtained from the Australian Institute of Health and Welfare (AIHW) from 1982 to 2013. Changes to the incidence, and the cancer-specific mortality following the diagnosis of ANs were analyzed over this time period, with stratification performed for histological subtype, gender, and age groups (<50y and ≥50y). RESULTS: Incidence and mortality rates of ANs increased significantly across both genders and age groups. Incidence rates increased by 415%, from 0.40/100 000 population in 1982 to 2.06/100 000 in 2013. Overall mortality rates increased by 130%, from 0.057/100 000 during 1982-1985 to 0.131/100 000 during 2010-2013. Controlling for age group and gender, the incidence rates increased by 20% every four years (Incidence rate ratio (IRR) = 1.20, 95% confidence interval (CI): 1.17, 1.23, global P value<0.0001), and controlling for age, the mortality rates increased by 8% every four years (IRR = 1.08, 95% CI: 1.00, 1.17, global P-value = 0.0401). CONCLUSION: The increasing use of CT scanning, improvements in pathological assessment of the appendix, and the growing aging population may have contributed in part to the apparent rise in the incidence of ANs.