Roie Etinger1, Doron Comaneshter2, Howard Amital1,3, Arnon D Cohen2,4, Shmuel Tiosano1,5. 1. Faculty of Medicine, Tel Aviv University Sackler, Tel Aviv, Israel. 2. Department of Quality Measurements and Research, Clalit Health Services, Tel-Aviv, Israel. 3. Department of Internal Medicine B and Research Center for Autoimmune Diseases, The Chaim Sheba Medical Center at Tel Ha Shomer, Ramat-Gan, Israel. 4. Siaal Research Center for Family Medicine and Primary Care, Ben-Gurion University of the Negev Faculty of Health Sciences, Beer Sheva, Southern Israel. 5. The Leviev Heart Center, Sheba Medical Center, Tel-Hashomer, Israel.
Abstract
OBJECTIVE: To evaluate the proportion and the long-term prognostic significance of heart failure (HF) in sarcoidosis patients. METHODS: Data extracted from a large Israeli healthcare provider's database were used to study sarcoidosis patients and matched non-sarcoidosis controls since 2000 to 2016. The proportion of HF was compared between the groups, and the associations between sarcoidosis, HF, and all-cause mortality were assessed. RESULTS: Included were 3,993 sarcoidosis patients and 19,856 age- and sex-matched controls. The proportion of HF patients was higher among the former (10.9% and 5.3%, respectively). A logistic regression model for multivariable analysis for covariates found sarcoidosis to be independently associated with HF (Odds Ratio (OR) 2.09 confidence interval (CI) 1.83-2.39). A total of 710 sarcoidosis patients (17.8%) and 2,121 controls (10.7%) died during the study period (p < 0.001). A multivariable survival analysis found an estimated hazard ratio (HR) of 1.84 (95%CI 1.67-2.02), indicating a significant association between sarcoidosis and risk for all-cause mortality. Our analysis also revealed a significant association between HF and risk for all-cause mortality (HR 3.05, 95%CI 2.77-3.36). CONCLUSIONS: Sarcoidosis is independently associated with HF, and both are independently associated with all-cause mortality.
OBJECTIVE: To evaluate the proportion and the long-term prognostic significance of heart failure (HF) in sarcoidosis patients. METHODS: Data extracted from a large Israeli healthcare provider's database were used to study sarcoidosis patients and matched non-sarcoidosis controls since 2000 to 2016. The proportion of HF was compared between the groups, and the associations between sarcoidosis, HF, and all-cause mortality were assessed. RESULTS: Included were 3,993 sarcoidosis patients and 19,856 age- and sex-matched controls. The proportion of HF patients was higher among the former (10.9% and 5.3%, respectively). A logistic regression model for multivariable analysis for covariates found sarcoidosis to be independently associated with HF (Odds Ratio (OR) 2.09 confidence interval (CI) 1.83-2.39). A total of 710 sarcoidosis patients (17.8%) and 2,121 controls (10.7%) died during the study period (p < 0.001). A multivariable survival analysis found an estimated hazard ratio (HR) of 1.84 (95%CI 1.67-2.02), indicating a significant association between sarcoidosis and risk for all-cause mortality. Our analysis also revealed a significant association between HF and risk for all-cause mortality (HR 3.05, 95%CI 2.77-3.36). CONCLUSIONS: Sarcoidosis is independently associated with HF, and both are independently associated with all-cause mortality.
Authors: Marios Rossides; Susanna Kullberg; Johan Grunewald; Anders Eklund; Daniela Di Giuseppe; Johan Askling; Elizabeth V Arkema Journal: Heart Date: 2021-05-21 Impact factor: 5.994