Literature DB >> 33019810

Localization and function of a Plasmodium falciparum protein (PF3D7_1459400) during erythrocyte invasion.

Emmanuel Amlabu1,2, Prince B Nyarko1, Grace Opoku1, Damata Ibrahim-Dey1, Philip Ilani1, Henrietta Mensah-Brown1, Grace A Akporh1, Ojo-Ajogu Akuh1, Evelyn A Ayugane1, David Amoh-Boateng1, Kwadwo A Kusi1,3, Gordon A Awandare1.   

Abstract

IMPACT STATEMENT: Plasmodium falciparum malaria is a global health problem. Erythrocyte invasion by P. falciparum merozoites appears to be a promising target to curb malaria. We have identified and characterized a novel protein that is involved in erythrocyte invasion. Our data on protein subcellular localization, stage-specific protein expression pattern, and merozoite invasion inhibition by α-peptide antibodies suggest a role for PF3D7_1459400 protein during P. falciparum erythrocyte invasion. Even more, the human immunoepidemiology data present PF3D7_1459400 protein as an immunogenic antigen which could be further exploited for the development of new anti-infective therapy against malaria.

Entities:  

Keywords:  Plasmodium falciparum; erythrocyte invasion; malaria vaccine; naturally acquired antibodies; peptide antibodies

Mesh：

Substances：

Year:  2020        PMID： 33019810      PMCID： PMC7797990          DOI： 10.1177/1535370220961764

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  38 in total

1.  A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray.

Authors:  Peter D Crompton; Matthew A Kayala; Boubacar Traore; Kassoum Kayentao; Aissata Ongoiba; Greta E Weiss; Douglas M Molina; Chad R Burk; Michael Waisberg; Algis Jasinskas; Xiaolin Tan; Safiatou Doumbo; Didier Doumtabe; Younoussou Kone; David L Narum; Xiaowu Liang; Ogobara K Doumbo; Louis H Miller; Denise L Doolan; Pierre Baldi; Philip L Felgner; Susan K Pierce
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-29       Impact factor: 11.205

2.  Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites.

Authors:  Mauld H Lamarque; Magali Roques; Marie Kong-Hap; Michelle L Tonkin; George Rugarabamu; Jean-Baptiste Marq; Diana M Penarete-Vargas; Martin J Boulanger; Dominique Soldati-Favre; Maryse Lebrun
Journal:  Nat Commun       Date:  2014-06-17       Impact factor: 14.919

3.  Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities.

Authors:  Danica A Helb; Kevin K A Tetteh; Philip L Felgner; Jeff Skinner; Alan Hubbard; Emmanuel Arinaitwe; Harriet Mayanja-Kizza; Isaac Ssewanyana; Moses R Kamya; James G Beeson; Jordan Tappero; David L Smith; Peter D Crompton; Philip J Rosenthal; Grant Dorsey; Christopher J Drakeley; Bryan Greenhouse
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-27       Impact factor: 11.205

4.  Profiling humoral immune responses to P. falciparum infection with protein microarrays.

Authors:  Denise L Doolan; Yunxiang Mu; Berkay Unal; Suman Sundaresh; Siddiqua Hirst; Conrad Valdez; Arlo Randall; Douglas Molina; Xiaowu Liang; Daniel A Freilich; J Aggrey Oloo; Peter L Blair; Joao C Aguiar; Pierre Baldi; D Huw Davies; Philip L Felgner
Journal:  Proteomics       Date:  2008-11       Impact factor: 3.984

5.  Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes.

Authors:  Jennifer C Volz; Alan Yap; Xavier Sisquella; Jenn K Thompson; Nicholas T Y Lim; Lachlan W Whitehead; Lin Chen; Marko Lampe; Wai-Hong Tham; Danny Wilson; Thomas Nebl; Danushka Marapana; Tony Triglia; Wilson Wong; Kelly L Rogers; Alan F Cowman
Journal:  Cell Host Microbe       Date:  2016-06-30       Impact factor: 21.023

Review 6.  The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.

Authors:  Alan F Cowman; Christopher J Tonkin; Wai-Hong Tham; Manoj T Duraisingh
Journal:  Cell Host Microbe       Date:  2017-08-09       Impact factor: 21.023

Review 7.  Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions.

Authors:  Jake Baum; Alexander G Maier; Robert T Good; Ken M Simpson; Alan F Cowman
Journal:  PLoS Pathog       Date:  2005-12-16       Impact factor: 6.823

8.  The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015.

Authors:  S Bhatt; D J Weiss; E Cameron; D Bisanzio; B Mappin; U Dalrymple; K Battle; C L Moyes; A Henry; P A Eckhoff; E A Wenger; O Briët; M A Penny; T A Smith; A Bennett; J Yukich; T P Eisele; J T Griffin; C A Fergus; M Lynch; F Lindgren; J M Cohen; C L J Murray; D L Smith; S I Hay; R E Cibulskis; P W Gething
Journal:  Nature       Date:  2015-09-16       Impact factor: 49.962

9.  Functional Characterization of Plasmodium falciparum Surface-Related Antigen as a Potential Blood-Stage Vaccine Target.

Authors:  Emmanuel Amlabu; Henrietta Mensah-Brown; Prince B Nyarko; Ojo-Ajogu Akuh; Grace Opoku; Philip Ilani; Richard Oyagbenro; Kwame Asiedu; Yaw Aniweh; Gordon A Awandare
Journal:  J Infect Dis       Date:  2018-07-24       Impact factor: 5.226

10.  Discovery of gene function by expression profiling of the malaria parasite life cycle.

Authors:  Karine G Le Roch; Yingyao Zhou; Peter L Blair; Muni Grainger; J Kathleen Moch; J David Haynes; Patricia De La Vega; Anthony A Holder; Serge Batalov; Daniel J Carucci; Elizabeth A Winzeler
Journal:  Science       Date:  2003-07-31       Impact factor: 47.728
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