| Literature DB >> 33019185 |
Rency S Varghese, Yuan Zhou, Yifan Chen, Megan E Barefoot, Mahlet Tadesse, Habtom W Ressom.
Abstract
In addition to socioeconomic influences, biological factors are believed to play a role in health disparities. In this paper, we investigate miRNA, mRNA, and DNA methylation patterns that contribute to disparities in hepatocellular carcinoma (HCC). This is accomplished by integration of mRNA-Seq, miRNA-Seq, and DNA methylation data we acquired by analysis of liver tissues from 30 HCC patients consisting of European Americans (EAs), African Americans (AAs), and Asian Americans (Asians). Mixed-ANOVA models are applied to identify miRNAs, mRNAs, and DNA methylation sites that are significantly altered in tumor vs. adjacent normal tissues in a race-specific manner. Through integrated analysis, a refined list of differentially expressed mRNAs is obtained by selecting those that are targets of differentially expressed miRNAs and consist of promoter regions that are differentially methylated.Entities:
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Year: 2020 PMID： 33019185 PMCID： PMC9576401 DOI： 10.1109/EMBC44109.2020.9176036
Source DB: PubMed Journal: Annu Int Conf IEEE Eng Med Biol Soc ISSN： 2375-7477