BACKGROUND: Absolute hyperaemic coronary blood flow (Q, in mL/min) and resistance (R, in Wood units [WU]) can be measured invasively by continuous thermodilution. AIMS: The aim of this study was to assess normal reference values of Q and R. METHODS: In 177 arteries (69 patients: 25 controls, i.e., without identifiable coronary atherosclerosis; 44 patients with mild, non-obstructive atherosclerosis), thermodilution-derived hyperaemic Q and total, epicardial, and microvascular absolute resistances (Rtot, Repi, and Rmicro) were measured. In 20 controls and 29 patients, measurements were obtained in all three major coronary arteries, thus allowing calculations of Q and R for the whole heart. In 15 controls (41 vessels) and 25 patients (71 vessels), vessel-specific myocardial mass was derived from coronary computed tomography angiography. RESULTS: Whole heart hyperaemic Q tended to be higher in controls compared to patients (668±185 vs 582±138 mL/min, p=0.068). In the left anterior descending coronary artery (LAD), hyperaemic Q was significantly higher (293±102 mL/min versus 228±71 mL/min, p=0.004) in controls than in patients. This was driven mainly by a difference in Repi (43±23 vs 83±41 WU, p=0.048), without significant differences in Rmicro. After adjustment for vessel-specific myocardial mass, hyperaemic Q was similar in the three vascular territories (5.9±1.9, 4.9±1.7, and 5.3±2.1 mL/min/g, p=0.44, in the LAD, left circumflex and right coronary artery, respectively). CONCLUSIONS: The present report provides reference values of absolute coronary hyperaemic Q and R. Q was homogeneously distributed in the three major myocardial territories but the large ranges of observed hyperaemic values of flow and of microvascular resistance preclude their clinical use for inter-patient comparison.
BACKGROUND: Absolute hyperaemic coronary blood flow (Q, in mL/min) and resistance (R, in Wood units [WU]) can be measured invasively by continuous thermodilution. AIMS: The aim of this study was to assess normal reference values of Q and R. METHODS: In 177 arteries (69 patients: 25 controls, i.e., without identifiable coronary atherosclerosis; 44 patients with mild, non-obstructive atherosclerosis), thermodilution-derived hyperaemic Q and total, epicardial, and microvascular absolute resistances (Rtot, Repi, and Rmicro) were measured. In 20 controls and 29 patients, measurements were obtained in all three major coronary arteries, thus allowing calculations of Q and R for the whole heart. In 15 controls (41 vessels) and 25 patients (71 vessels), vessel-specific myocardial mass was derived from coronary computed tomography angiography. RESULTS: Whole heart hyperaemic Q tended to be higher in controls compared to patients (668±185 vs 582±138 mL/min, p=0.068). In the left anterior descending coronary artery (LAD), hyperaemic Q was significantly higher (293±102 mL/min versus 228±71 mL/min, p=0.004) in controls than in patients. This was driven mainly by a difference in Repi (43±23 vs 83±41 WU, p=0.048), without significant differences in Rmicro. After adjustment for vessel-specific myocardial mass, hyperaemic Q was similar in the three vascular territories (5.9±1.9, 4.9±1.7, and 5.3±2.1 mL/min/g, p=0.44, in the LAD, left circumflex and right coronary artery, respectively). CONCLUSIONS: The present report provides reference values of absolute coronary hyperaemic Q and R. Q was homogeneously distributed in the three major myocardial territories but the large ranges of observed hyperaemic values of flow and of microvascular resistance preclude their clinical use for inter-patient comparison.
Authors: Louise Aubiniere-Robb; Rebecca Gosling; Daniel J Taylor; Tom Newman; D Rodney; Hose Ian Halliday; Patricia V Lawford; Andrew J Narracott; Julian P Gunn; Paul D Morris Journal: Nat Cardiovasc Res Date: 2022-07-04
Authors: Federico Marin; Roberto Scarsini; Dimitrios Terentes-Printzios; Rafail A Kotronias; Flavio Ribichini; Adrian P Banning; Giovanni Luigi De Maria Journal: Curr Cardiol Rev Date: 2022
Authors: Daniëlle C J Keulards; Mohamed El Farissi; Pim A L Tonino; Koen Teeuwen; Pieter-Jan Vlaar; Eduard van Hagen; Inge F Wijnbergen; Annemiek de Vos; Guus R G Brueren; Marcel Van't Veer; Nico H J Pijls Journal: J Interv Cardiol Date: 2020-11-17 Impact factor: 2.279
Authors: Muhammad Sabbah; Niels Thue Olsen; Mikko Minkkinen; Lene Holmvang; Hans-Henrik Tilsted; Frants Pedersen; Francis R Joshi; Kiril Ahtarovski; Rikke Sørensen; Jesper James Linde; Lars Søndergaard; Nico Pijls; Jacob Lønborg; Thomas Engstrøm Journal: J Am Heart Assoc Date: 2022-04-26 Impact factor: 6.106