| Literature DB >> 33016066 |
Hongji Liu1,2,3, Xiaotong Lv1,2,4, Junchao Qian5, Hong Li1,4, Yong Qian1,3, Xingyu Wang1,2,3, Xiangfu Meng1,2,3, Wenchu Lin1,4, Hui Wang1,3,4.
Abstract
Rational design of metal-free multifunctional therapeutic reagents offers great opportunities for cancer treatment in the clinic. Here, graphitic carbon nitride (g-C3N4) quantum dots embedded in carbon nanosheets (CNQD-CN) are in situ prepared via a one-pot hydrothermal approach with formamide as carbon and nitrogen source. The CNQD-CN not only serves as an excellent near-infrared (NIR) fluorescent marker but also acts as a pH-responsive nanocarrier. Moreover, the CNQD-CN possesses both light-to-heat conversion and singlet oxygen generation capabilities under a single NIR excitation wavelength. Further investigations show that systemic delivery of doxorubicin (DOX) using the multifunctional CNQD-CN nanocarrier under NIR irradiation was highly effective to cause cancer cell apoptosis in vitro and inhibit tumor growth in vivo. CNQD-CN represents a multifunctional therapeutic platform for synchronous cancer imaging and treatment through the synergistic effect of phototherapy and chemotherapy.Entities:
Keywords: C3N4 quantum dots; NIR imaging; carbon nanosheets; combined therapy; synergistic effect
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Year: 2020 PMID： 33016066 DOI： 10.1021/acsnano.0c05143
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881