Lisa R Rogers1, Quinn T Ostrom2, Julia Schroer3, Jaime Vengoechea4, Li Li3, Stanton Gerson3, Charles J Nock3,5, Mitchell Machtay3,6, Warren Selman1,3, Simon Lo7, Andrew E Sloan1,3,8, Jill S Barnholtz-Sloan3,9. 1. Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio. 2. Department of Medicine, Section of Epidemiology and Population Health, Baylor College of Medicine, Houston, Texas. 3. Case Western Reserve University School of Medicine, Cleveland, Ohio. 4. Division of Medical Genetics, Emory University School of Medicine, Atlanta, Georgia. 5. Department of Hematology and Oncology, University Hospitals, Cleveland, Ohio. 6. Department of Radiation Oncology, University Hospitals, Cleveland, Ohio. 7. Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington. 8. Case Comprehensive Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, Ohio. 9. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.
Abstract
BACKGROUND: Metabolic syndrome is identified as a risk factor for the development of several systemic cancers, but its frequency among patients with glioblastoma and its association with clinical outcomes have yet to be determined. The aim of this study was to investigate metabolic syndrome as a risk factor for and affecting survival in glioblastoma patients. METHODS: A retrospective cohort study, consisting of patients with diagnoses at a single institution between 2007 and 2013, was conducted. Clinical records were reviewed, and clinical and laboratory data pertaining to 5 metabolic criteria were extrapolated. Overall survival was determined by time from initial surgical diagnosis to date of death or last follow-up. RESULTS: The frequency of metabolic syndrome among patients diagnosed with glioblastoma was slightly greater than the frequency of metabolic syndrome among the general population. Within a subset of patients (n = 91) receiving the full schedule of concurrent radiation and temozolomide and adjuvant temozolomide, median overall survival was significantly shorter for patients with metabolic syndrome compared with those without. In addition, the presence of all 5 elements of the metabolic syndrome resulted in significantly decreased median survival in these patients. CONCLUSIONS: We identified the metabolic syndrome at a slightly higher frequency in patients with diagnosed glioblastoma compared with the general population. In addition, metabolic syndrome with each of its individual components is associated with an overall worse prognosis in patients receiving the standard schedule of radiation and temozolomide after adjustment for age.
BACKGROUND: Metabolic syndrome is identified as a risk factor for the development of several systemic cancers, but its frequency among patients with glioblastoma and its association with clinical outcomes have yet to be determined. The aim of this study was to investigate metabolic syndrome as a risk factor for and affecting survival in glioblastoma patients. METHODS: A retrospective cohort study, consisting of patients with diagnoses at a single institution between 2007 and 2013, was conducted. Clinical records were reviewed, and clinical and laboratory data pertaining to 5 metabolic criteria were extrapolated. Overall survival was determined by time from initial surgical diagnosis to date of death or last follow-up. RESULTS: The frequency of metabolic syndrome among patients diagnosed with glioblastoma was slightly greater than the frequency of metabolic syndrome among the general population. Within a subset of patients (n = 91) receiving the full schedule of concurrent radiation and temozolomide and adjuvant temozolomide, median overall survival was significantly shorter for patients with metabolic syndrome compared with those without. In addition, the presence of all 5 elements of the metabolic syndrome resulted in significantly decreased median survival in these patients. CONCLUSIONS: We identified the metabolic syndrome at a slightly higher frequency in patients with diagnosed glioblastoma compared with the general population. In addition, metabolic syndrome with each of its individual components is associated with an overall worse prognosis in patients receiving the standard schedule of radiation and temozolomide after adjustment for age.
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